Free radical-induced oxidation of glycerophosphocholine lipids and formation of biologically active products.
Free radical-induced oxidation of glycerophosphocholine lipids and formation of biologically active products.
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自由基诱导的甘油磷酸胆碱脂质氧化和生物活性产物的形成。
DOI：
10.1007/978-1-4899-0179-8_10
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发表时间：
1996
影响因子：
--
通讯作者：
Murphy,RC
中科院分区：
文献类型：
--
作者：
Murphy,RC
脂质介质是一类来源于磷脂的生物活性化合物，被认为在生理过程和病理生理事件中都起着重要作用。也许研究得最好的一类脂质介质是从花生四烯酸中提取的，称为类二十烷酸。已知有几种酶系统参与它们的形成，包括前列腺素H合成酶，它催化环内过氧化物的形成，环内过氧化物是前列腺素、血栓素和前列腺环素的直接前体。白三烯由花生四烯酸通过5-脂氧合酶形成，该酶最初将氧引入花生四烯酸骨架2。其他具有生物活性的类二十烷酸是由15-脂氧合酶3、12-脂氧合酶4和细胞色素P-4505形成的。这些酶使用未酯化的花生四烯酸作为底物。另一类重要的脂质介质是血小板活化因子，它来源于醚类磷脂，在n-2位置有醋酸盐。前体溶酶甘油磷胆碱的形成以及随后的乙酰化过程都是酶介导的。
Lipid mediators are a diverse family of biologically active compounds derived from phospholipids and are thought to play important roles both in physiological processes as well as pathophysiologic events. Perhaps the best studied class of lipid mediators are those derived from arachidonic acid, termed eicosanoids. Several enzymatic systems are known to be involved in their formation including prostaglandin H synthase which catalyzes the formation of cyclic endoperoxides, the direct precursor of prostaglandins, thromboxane, and prostacyclinl. Leukotrienes are formed from arachidonic acid by the enzyme 5-lipoxygenase which initially introduces oxygen into the arachidonic acid backbone2. Other biologically active eicosanoids are formed by 15-lipoxygenase3, 12-lipoxygenase4, and cytochrome P-4505. These enzymes use nonesterified arachidonic acid as substrate. Another important class of lipid mediator is platelet-activating factor which is derived from ether phospholipids and has acetate at thesn-2 position. The formation of the precursor lyso glycerophosphocholine as well as the subsequent acetylation process are enzymatically mediated’.