Neurodevelopmental mechanisms linking early experiences and mental health: Translating science to promote well-being among youth.
Neurodevelopmental mechanisms linking early experiences and mental health: Translating science to promote well-being among youth.
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DOI：
10.1037/amp0001107
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发表时间：
2022-12
影响因子：
16.4
通讯作者：
Gee, Dylan G
中科院分区：
文献类型：
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作者：
Gee, Dylan G
早期经历可能对心理健康产生深远而持久的影响。描绘与逆境暴露后的风险和复原力相关的神经发育途径对于促进福祉和有针对性的干预至关重要。一个快速增长的跨物种文献促进了识别神经和行为机制的进展，将早期经验与心理健康联系起来，突出了皮质边缘回路在学习和情绪调节中的核心作用。基于与压力和缓冲因素相关的皮质边缘发育的知识，我们描述了心理健康结果中逆境的发展时机和经验要素的重要性。最后，我们讨论了将大脑发育知识和早期经验转化为优化青少年精神病理干预措施的机会，并为促进社会健康发展的政策提供信息。
Early experiences can have profound and lasting effects on mental health. Delineating neurodevelopmental pathways related to risk and resilience following adversity exposure is critical for promoting well-being and targeting interventions. A rapidly growing cross-species literature has facilitated advances in identifying neural and behavioral mechanisms linking early experiences with mental health, highlighting a central role of corticolimbic circuitry involved in learning and emotion regulation. Building upon knowledge of corticolimbic development related to stress and buffering factors, we describe the importance of the developmental timing and experiential elements of adversity in mental health outcomes. Finally, we discuss opportunities to translate knowledge of the developing brain and early experiences to optimize interventions for youth with psychopathology and to inform policy that promotes healthy development at the societal level.