Dynamic coronary MR angiography and first-pass perfusion with intracoronary administration of contrast agent
Dynamic coronary MR angiography and first-pass perfusion with intracoronary administration of contrast agent
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DOI：
10.1002/jmri.10161
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发表时间：
2002-09-01
影响因子：
4.4
通讯作者：
Gropler, RJ
中科院分区：
文献类型：
--
作者：
Tsekos, NV;Woodard, PK;Gropler, RJ
目的：评价冠状动脉内低剂量Gd造影剂能否进行冠状动脉动态成像，以及长时间多次注射对图像信噪比(SNR)和对比噪声比(CNR)的影响。材料和方法：采用冠状动脉内低剂量Gd造影剂进行动态磁共振(MR)成像(130毫秒/像)和造影剂首过心肌灌注研究。应用快速多层梯度回波(GRE)序列对犬(N=4)进行MR造影剂扫描。结果：在长达2.3分钟的时间内，增强后的冠状动脉成像清晰。在多次连续的血管造影术中，增强的冠状动脉的SNR和CNR基本保持不变。结论：冠脉内注射Gd可获得高时间分辨率的冠状动脉磁共振血管成像(MRA)，多次低剂量缓慢注射Gd可在不影响血管SNR和CNR的情况下进行多次缓慢灌注。
Purpose: to evaluate whether dynamic imaging of the coronary arteries can be performed with intracoronary infusion of low-dose gadolinium (Gd)-based contrast agent and assess the effect of long duration and multiple infusions on the image signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR).Materials and Methods: Dynamic coronary magnetic resonance (MR) imaging (130 msec/image) and contrast agent first pass myocardial perfusion studies were performed with intracoronary infusions of low-dose Gd-based. MR contrast agent on dogs (N = 4) using a fast multislice gradient recalled echo (GRE) sequence.Results: Contrast-enhanced coronary arteries were clearly imaged during infusion periods as long as 2.3 minutes. The SNR and CNR of the contrast-enhanced coronary arteries remained essentially unchanged over multiple consecutive angiographic sessions. In addition, we demonstrated that first pass studies performed with intracoronary injection of MR contrast agent can be used as a means of assessing regional myocardial perfusion.Conclusion: These studies demonstrated that, using intracoronary infusion of Gd, coronary magnetic resonance angiography (MRA) can be performed with high temporal resolution, and multiple low-dose slow infusions of Gd-based MR contrast agent can be performed without compromise of the vessel SNR and CNR.