Periodontal therapy may reduce the risk of preterm low birth weight in women with periodontal disease:: A randomized controlled trial
Periodontal therapy may reduce the risk of preterm low birth weight in women with periodontal disease:: A randomized controlled trial
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DOI：
10.1902/jop.2002.73.8.911
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发表时间：
2002-08-01
影响因子：
4.3
通讯作者：
Gutierrez, J
中科院分区：
文献类型：
--
作者：
López, NJ;Smith, PC;Gutierrez, J
背景：最近的研究表明，牙周病是早产低出生体重（PLBW）的危险因素。进行了一项随机对照试验，以帮助进一步评估牙周病与 PLBW 之间的关联。方法：纳入了 400 名 18 至 35 岁患有牙周病的孕妇，她们在智利圣地亚哥接受产前护理。妇女被随机分配到妊娠 28 周前接受牙周治疗的实验组 (n = 200) 或分娩后接受牙周治疗的对照组 (n = 200)。以前和当前的怀孕情况以及已知的风险因素是从患者的医疗记录和访谈中获得的。评估的主要结局是妊娠 37 周以下的分娩或体重低于 2,500 克的婴儿。 结果：在 400 名入组妇女中，有 49 名因不同原因被排除在分析之外。治疗组PLBW的发生率为1.84%（3/163），对照组为10.11%（19/188）（优势比[OR]5.49，95%置信区间[CI]1.65至18.22，P=0.001）。多变量logistic回归分析显示，牙周疾病是与PLBW相关的最强因素（OR 4.70，95% CI 1.29至17.13）。与此类分娩显着相关的其他因素包括：既往 PLBW（OR 3.98，95% CI 1.11 至 14.21）、少于 6 次产前检查（OR 3.70，95% CI 1.46 至 9.38）以及母亲体重增加较低（OR 3.42，95% CI 1.16 至 10.03）。 结论：牙周病似乎与PLBW 的独立危险因素。牙周治疗显着降低了患有牙周病的女性人群中 PLBW 的发生率。
Background: Recent studies have suggested that periodontal disease is a risk factor for preterm low birth weight (PLBW). A randomized controlled trial was undertaken to help further evaluate the proposed association between periodontal disease and PLBW.Methods: Four hundred pregnant women with periodontal disease, aged 18 to 35, were enrolled while receiving prenatal care in Santiago, Chile. Women were randomly assigned to either an experimental group (n = 200), which received periodontal treatment before 28 weeks of gestation or to a control group (n = 200) which received periodontal treatment after delivery. Previous and current pregnancies and known risk factors were obtained from patient medical records and interviews. The primary outcome assessed was the delivery at less than 37 weeks of gestation or an infant weighing less than 2,500 g.Results: Of the 400 women enrolled, 49 were excluded from the analyses for different reasons. The incidence of PLBW in the treatment group was 1.84% (3/163) and in the control group was 10.11% (19/188), (odds ratio [OR] 5.49, 95% confidence interval [CI] 1.65 to 18.22, P = 0.001). Multivariate logistic regression analysis showed that periodontal disease was the strongest factor related to PLBW (OR 4.70, 95% CI 1.29 to 17.13). Other factors significantly associated with such deliveries were: previous PLBW (OR 3.98, 95% CI 1.11 to 14.21), less than 6 prenatal visits (OR 3.70, 95% CI 1.46 to 9.38), and maternal low weight gain (OR 3.42, 95% CI 1.16 to 10.03).Conclusions: Periodontal disease appears to be an independent risk factor for PLBW. Periodontal therapy significantly reduces the rates of PLBW in this population of women with periodontal disease.