Activity Participation and Cognitive Aging from Age 50 to 80 in the Glostrup 1914 Cohort
Activity Participation and Cognitive Aging from Age 50 to 80 in the Glostrup 1914 Cohort
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DOI：
10.1111/j.1532-5415.2012.04168.x
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发表时间：
2012-10-01
影响因子：
6.3
通讯作者：
Avlund, Kirsten
中科院分区：
文献类型：
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作者：
Gow, Alan J.;Mortensen, Erik L.;Avlund, Kirsten
目的考察休闲和体育活动对认知的保护作用，同时考虑先前的认知能力，这是以前报道的活动和认知老化之间的一个很少被认为是混淆的因素。设计纵向队列研究。背景：Glostrup，丹麦。参与者被招募到Glostrup 1914年队列的成年人的社区居住样本(基线N=802)。所有人都出生于1914年，分别在50岁、60岁、70岁和80岁接受评估。在研究期间招募了新的参与者来对抗自然减员。每一次的测量都使用四个测试来评估认知能力，这四个测试定义了一个总的认知能力分数。还收集了自我报告的参与休闲和体育活动的情况。总体而言，体力活动按3分或4分制进行总结，休闲活动按不参加或有参加(50岁和60岁)或根据参与一系列共同活动(70岁)进行总结。在生长曲线模型中考察了运动、休闲和体力活动对60-80岁儿童认知能力水平和认知随时间变化的影响。结果运动量越大(休闲或体力)，认知能力水平越高。对基线认知能力(50岁)进行调整后，这些关联减弱，这表明老年时报告的活动和认知之间的关联在很大程度上是保留分化的结果。60或70岁时较多的体力活动与较少的认知衰退之间存在着一种虽小但重要的联系。结论更频繁的休闲活动和较少的认知衰退之间的关联主要反映了活动和认知之间的正向横向关联，尽管更多的体力活动和更成功的认知老化轨迹之间的联系对于那些正在制定干预措施的人来说尤其相关。
Objectives To examine the cognitively protective effect of leisure and physical activities while accounting for prior cognitive ability, a rarely considered confounder of the previously reported associations between activity and cognitive aging. Design Longitudinal cohort study. Setting Glostrup, Denmark. Participants Community-dwelling sample of adults recruited into the Glostrup 1914 Cohort (baseline N = 802). All were born in 1914 and were assessed at ages 50, 60, 70, and 80. New participants were recruited during the study to counter attrition. Measurements On each occasion, cognitive ability was assessed using four tests, which defined a general cognitive ability score. Self-reported participation in leisure and physical activities was also collected. In general, physical activity was summarized on a 3- or 4-point scale, and leisure activity as none versus some (ages 50 and 60) or according to participation in a list of common activities (age 70). The effect of activityleisure and physicalon the level of cognitive ability and cognitive change over time from age 60 to 80 was examined in growth curve models. Results Greater activity (leisure or physical) was consistently associated with a higher level of cognitive ability. Adjusting for baseline cognitive ability (age 50) attenuated these associations, suggesting that associations between activity and cognition reported in old age are largely a consequence of preserved differentiation. A small but significant association remained between greater physical activity at age 60 or 70 and less cognitive decline. Conclusion The association between more-frequent leisure activity and less cognitive decline mainly reflects the positive cross-sectional association between activity and cognition, although the link that remains between greater physical activity and a more-successful cognitive aging trajectory is of particular relevance to those who are developing interventions.