Survival of patients with stage I lung cancer detected on CT screening
Survival of patients with stage I lung cancer detected on CT screening
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DOI：
10.1056/nejmoa060476
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发表时间：
2006-10-26
影响因子：
158.5
通讯作者：
Miettinen, Olli S.
中科院分区：
文献类型：
--
作者：
Henschke, Claudia I.;Yankelevitz, David F.;Miettinen, Olli S.
在一项大型合作研究中，我们使用低剂量CT对31，567名无症状的肺癌高危人群进行了筛查，从1993年到2005年，从1994年到2005年，456次重复筛查在上次筛查后7至18个月进行。我们估计了在CT筛查中检测到并通过活检诊断的临床I期肺癌参与者的10年肺癌特异性生存率，无论接受何种治疗，以及在1个月内接受临床I期癌症手术切除的参与者。一个病理小组审查了手术标本从参与者接受surgence.ResultsScreening导致484参与者肺癌的诊断。在这些参与者中，412例（85%）患有临床I期肺癌，该亚组的估计10年生存率为88%（95%置信区间[CI]，84至91）。在诊断后1个月内接受手术切除的302名临床I期癌症参与者中，生存率为92%（95%CI，88至95）。没有接受治疗的临床I期癌症的8名参与者在诊断后5年内死亡。ConclusionsAnnual Spiral CT Screening可以检测出肺癌是可治愈的。
BackgroundThe outcome among patients with clinical stage I cancer that is detected on annual screening using spiral computed tomography (CT) is unknown.MethodsIn a large collaborative study, we screened 31,567 asymptomatic persons at risk for lung cancer using low-dose CT from 1993 through 2005, and from 1994 through 2005, 27,456 repeated screenings were performed 7 to 18 months after the previous screening. We estimated the 10-year lung-cancer–specific survival rate among participants with clinical stage I lung cancer that was detected on CT screening and diagnosed by biopsy, regardless of the type of treatment received, and among those who underwent surgical resection of clinical stage I cancer within 1 month. A pathology panel reviewed the surgical specimens obtained from participants who underwent resection.ResultsScreening resulted in a diagnosis of lung cancer in 484 participants. Of these participants, 412 (85%) had clinical stage I lung cancer, and the estimated 10-year survival rate was 88% in this subgroup (95% confidence interval [CI], 84 to 91). Among the 302 participants with clinical stage I cancer who underwent surgical resection within 1 month after diagnosis, the survival rate was 92% (95% CI, 88 to 95). The 8 participants with clinical stage I cancer who did not receive treatment died within 5 years after diagnosis.ConclusionsAnnual spiral CT screening can detect lung cancer that is curable.