The HORMA domain: a common structural denominator in mitotic checkpoints, chromosome synapsis and DNA repair
The HORMA domain: a common structural denominator in mitotic checkpoints, chromosome synapsis and DNA repair
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DOI：
10.1016/s0968-0004(98)01257-2
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发表时间：
1998-08-01
影响因子：
13.8
通讯作者：
Koonin, EV
中科院分区：
文献类型：
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作者：
Aravind, L;Koonin, EV
我们饶有兴趣地阅读了Aravind及其同事最近在TiBS上发表的一篇论文1，在这篇论文中，作者表明p型atp酶属于一个大的酶超家族，其中包括卤酸脱卤酶、磷酸甘氨转氨酶和磷酸丝氨酸磷酸酶。p型atp酶与这些酶共享三个基序。作者注意到，这些基序中的第一个（基序I）包含一个保守的天冬氨酸残基，该残基已被证明与p型ATPases2中的磷酸基团和卤酸脱卤酶3中的一羟基酸共价结合。
We read with great interest the recent paper in TiBS by Aravind and colleagues1, in which the authors show that P-type ATPases belong to a large superfamily of enzymes that contains, among others, haloacid dehalogenase, phosphomannomutase and phosphoserine phosphatase. P-type ATPases share three motifs with these enzymes. The authors noticed that the first of these motifs (motif I) contains a conserved aspartate residue that has been shown to bind covalently to the phosphate group in P-type ATPases2 and to an-hydroxy acid in haloacid dehalogenases3.