THE SITE OF ATTACHMENT IN HUMAN RHINOVIRUS-14 FOR ANTIVIRAL AGENTS THAT INHIBIT UNCOATING
THE SITE OF ATTACHMENT IN HUMAN RHINOVIRUS-14 FOR ANTIVIRAL AGENTS THAT INHIBIT UNCOATING
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DOI：
10.1126/science.3018924
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发表时间：
1986-09-19
期刊：
影响因子：
56.9
通讯作者：
OTTO, MJ
中科院分区：
文献类型：
--
作者：
SMITH, TJ;KREMER, MJ;OTTO, MJ
Win 51711和Win 52084是结构相关的抗病毒化合物，可抑制犀牛(普通感冒)病毒和相关小核糖核酸病毒的复制。它们阻止了pH介导的病毒RNA的脱壳。这些化合物由3-甲基异恶唑基和4-恶唑基苯氧基(OP)组成，其中3-甲基异恶唑基插入VP1β-桶的疏水内部，连接的七元脂肪链和4-恶唑烷基苯氧基(OP)覆盖在峡谷底部的离子通道的入口。病毒的分解可以通过防止VP1疏水口袋的坍塌或通过阻止离子流入病毒内部来抑制。
WIN 51711 and WIN 52084 are structurally related, antiviral compounds that inhibit the replication of rhino (common cold) viruses and related picornaviruses. They prevent the pH-mediated uncoating of the viral RNA. The compounds consist of a 3-methylisoxazole group that inserts itself into the hydrophobic interior of the VP1 .beta.-barrel, a connecting seven-membered aliphatic chain, and a 4-oxazolinylphenoxy group (OP) that covers the entrance to an ion channel in the floor of the "canyon". Viral disassembly may be inhibited by preventing the collapse of the VP1 hydrophobic pocket or by blocking the flow of ions into the virus interior.