INFLUENCE OF SEX DIFFERENCE ON PHARMACOLOGICAL ACTION AND METABOLISM OF SOME DRUGS
INFLUENCE OF SEX DIFFERENCE ON PHARMACOLOGICAL ACTION AND METABOLISM OF SOME DRUGS
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DOI：
10.1016/0006-2952(62)90077-1
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发表时间：
1962-01-01
影响因子：
5.8
通讯作者：
FRONTINO, G
中科院分区：
文献类型：
--
作者：
KATO, R;CHIESARA, E;FRONTINO, G
戊巴比妥、异丙醇、士的宁、OMPA对成年大鼠的药理作用存在性别差异。这些性别差异也证明了体外使用肝切片和微粒体部分，并通过体内代谢研究。它们被阉割和性激素治疗所改变。雄性性激素的合成代谢作用似乎解释了雄性大鼠体内酶活性增加的原因。
A sex difference in the pharmacological effects of pentobar-bital, carisoprodol, strychnine, OMPA in adult rats has been demonstrated. These sex differences were also demonstrated in vitro using liver slices and microsomal fractions, and by in vivo metabolic studies. They were modified by castration and by sex hormones treatments. The anabolic action of male sex hormones appears to account for the increased enzyme activities in male rats.