FAST: a Feasible, Accurate and Speedy Test Strategy for COVID-19
FAST: a Feasible, Accurate and Speedy Test Strategy for COVID-19
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FAST：针对 COVID-19 的可行、准确和快速的测试策略
DOI：
10.1101/2020.06.04.20122473
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Qing Yang
中科院分区：
文献类型：
--
作者：
Linjiajie Fang;Shen Ling;Bing;Qing Yang
随着COVID-19大流行在全球范围内的持续，迫切需要尽可能快速准确地发现受感染患者。以色列理工学院b[2]提出的分组测试可以大大提高效率。然而，假阴性率（FNR）将增加一倍。以美国为例，团体测试将有超过70,000个假阴性，而个人测试则有35,000个假阴性。在本文中，我们提出了一种灵活、准确和快速的测试（FAST），它比现有的任何测试都更快、更准确。FAST首先形成小的密切接触小组，例如家庭和朋友。然后，在RT-PCR测试完成之前，将子组汇集成更大的组。FAST需要与以色列理工学院的方法进行类似数量的测试，但可以将FNR大幅降低到可以忽略不计的水平。再次以美国为例，FAST将假阴性的数量减少到2000，而比个人检测快7倍。
As the COVID-19 pandemic continues worldwide, there is an urgent need to detect infected patients as quickly and accurately as possible. Group testing proposed by Technion [2] could improve efficiency greatly. However, the false negative rate (FNR) would be doubled. Using USA as an example, group testing would have over 70,000 false negatives, compared to 35,000 false negatives by individual testing. In this paper, we propose a Flexible, Accurate and Speedy Test (FAST), which is faster and more accurate than any existing tests. FAST first forms small close contact subgroups, e.g. families and friends. It then pools subgroups to form larger groups before RT-PCR test is done. FAST needs a similar number of tests to Technion's method, but could sharply reduce the FNR to a negligible level. Again taking USA as example, FAST reduces the number of false negatives to just 2000 while it is seven times faster than individual testing.