Hemoglobin a1c and the progression of coronary artery calcification among adults without diabetes.
Hemoglobin a1c and the progression of coronary artery calcification among adults without diabetes.
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DOI：
10.2337/dc14-0360
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发表时间：
2015-01
期刊：
影响因子：
16.2
通讯作者：
Lewis CE
中科院分区：
文献类型：
--
作者：
Carson AP;Steffes MW;Carr JJ;Kim Y;Gross MD;Carnethon MR;Reis JP;Loria CM;Jacobs DR Jr;Lewis CE
较高水平的血红蛋白A1 c（HbA 1c）与无糖尿病个体的心血管疾病风险增加相关，也可能与冠状动脉钙化（CAC）呈正相关。本研究调查了年轻成人冠状动脉风险发展研究中HbA 1c与CAC进展的相关性。我们纳入了2，076名基线（2005-2006）时评估HbA 1c和非造影计算机断层扫描（CT）的参与者，并在5年后（2010-2011）重复CT。CAC进展定义为1）偶发CAC（基线时无CAC的患者中增加>0 Agatston单位），2）任何CAC进展（检查之间增加>10 Agatston单位），和3）晚期CAC进展（检查之间增加>100 Agatston单位）。在5年随访期间，12.9%没有基线CAC的参与者发生了CAC事件;在所有参与者中，18.2%出现任何CAC进展，5.4%出现晚期CAC进展。调整社会人口学因素后，HbA 1c升高与CAC事件（风险比[RR] = 1.45; 95% CI 1.02，2.06）、任何CAC进展（RR = 1.51; 95% CI 1.16，1.96）和晚期CAC进展（RR = 2.42; 95% CI 1.47，3.99）相关。对心血管风险因素进行额外调整后，降低了HbA 1c与CAC事件（RR = 1.05; 95% CI 0.74，1.49）和任何CAC进展（RR = 1.13; 95% CI 0.87，1.47）的相关性。相比之下，在多变量校正模型中，HbA 1c与晚期CAC进展的相关性持续存在（RR = 1.78; 95% CI 1.08，2.95）。在无糖尿病的个体中，HbA 1c升高与晚期CAC进展独立相关，而与CAC事件和任何CAC进展的相关性由其他已确定的心血管危险因素解释。
Higher levels of hemoglobin A1c (HbA1c) are associated with increased cardiovascular disease risk among individuals without diabetes and may also be positively associated with coronary artery calcification (CAC). This study investigated the association of HbA1c with CAC progression in the Coronary Artery Risk Development in Young Adults study. We included 2,076 participants with HbA1c and noncontrast computed tomography (CT) assessed at baseline (2005–2006), and CT repeated 5 years later (2010–2011). CAC progression was defined as 1) incident CAC (increase >0 Agatston units among those with no CAC at baseline), 2) any CAC progression (increase >10 Agatston units between examinations), and 3) advanced CAC progression (increase >100 Agatston units between examinations). During the 5-year follow-up period, 12.9% of participants without baseline CAC developed incident CAC; among all participants, 18.2% had any CAC progression and 5.4% had advanced CAC progression. Higher HbA1c was associated with incident CAC (risk ratio [RR] = 1.45; 95% CI 1.02, 2.06), any CAC progression (RR = 1.51; 95% CI 1.16, 1.96), and advanced CAC progression (RR = 2.42; 95% CI 1.47, 3.99) after adjustment for sociodemographic factors. Additional adjustment for cardiovascular risk factors attenuated the associations of HbA1c with incident CAC (RR = 1.05; 95% CI 0.74, 1.49) and any CAC progression (RR = 1.13; 95% CI 0.87, 1.47). In contrast, the association of HbA1c with advanced CAC progression persisted in multivariable adjusted models (RR = 1.78; 95% CI 1.08, 2.95). Higher HbA1c was independently associated with advanced CAC progression among individuals without diabetes, while the associations with incident CAC and any CAC progression were accounted for by other established cardiovascular risk factors.
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影响因子：
7.7
作者：
Soranzo N;Sanna S;Wheeler E;Gieger C;Radke D;Dupuis J;Bouatia-Naji N;Langenberg C;Prokopenko I;Stolerman E;Sandhu MS;Heeney MM;Devaney JM;Reilly MP;Ricketts SL;Stewart AF;Voight BF;Willenborg C;Wright B;Altshuler D;Arking D;Balkau B;Barnes D;Boerwinkle E;Böhm B;Bonnefond A;Bonnycastle LL;Boomsma DI;Bornstein SR;Böttcher Y;Bumpstead S;Burnett-Miller MS;Campbell H;Cao A;Chambers J;Clark R;Collins FS;Coresh J;de Geus EJ;Dei M;Deloukas P;Döring A;Egan JM;Elosua R;Ferrucci L;Forouhi N;Fox CS;Franklin C;Franzosi MG;Gallina S;Goel A;Graessler J;Grallert H;Greinacher A;Hadley D;Hall A;Hamsten A;Hayward C;Heath S;Herder C;Homuth G;Hottenga JJ;Hunter-Merrill R;Illig T;Jackson AU;Jula A;Kleber M;Knouff CW;Kong A;Kooner J;Köttgen A;Kovacs P;Krohn K;Kühnel B;Kuusisto J;Laakso M;Lathrop M;Lecoeur C;Li M;Li M;Loos RJ;Luan J;Lyssenko V;Mägi R;Magnusson PK;Mälarstig A;Mangino M;Martínez-Larrad MT;März W;McArdle WL;McPherson R;Meisinger C;Meitinger T;Melander O;Mohlke KL;Mooser VE;Morken MA;Narisu N;Nathan DM;Nauck M;O'Donnell C;Oexle K;Olla N;Pankow JS;Payne F;Peden JF;Pedersen NL;Peltonen L;Perola M;Polasek O;Porcu E;Rader DJ;Rathmann W;Ripatti S;Rocheleau G;Roden M;Rudan I;Salomaa V;Saxena R;Schlessinger D;Schunkert H;Schwarz P;Seedorf U;Selvin E;Serrano-Ríos M;Shrader P;Silveira A;Siscovick D;Song K;Spector TD;Stefansson K;Steinthorsdottir V;Strachan DP;Strawbridge R;Stumvoll M;Surakka I;Swift AJ;Tanaka T;Teumer A;Thorleifsson G;Thorsteinsdottir U;Tönjes A;Usala G;Vitart V;Völzke H;Wallaschofski H;Waterworth DM;Watkins H;Wichmann HE;Wild SH;Willemsen G;Williams GH;Wilson JF;Winkelmann J;Wright AF;WTCCC;Zabena C;Zhao JH;Epstein SE;Erdmann J;Hakonarson HH;Kathiresan S;Khaw KT;Roberts R;Samani NJ;Fleming MD;Sladek R;Abecasis G;Boehnke M;Froguel P;Groop L;McCarthy MI;Kao WH;Florez JC;Uda M;Wareham NJ;Barroso I;Meigs JB
通讯作者：
Meigs JB
影响因子：
120.7
作者：
Greenland, P;LaBree, L;Detrano, RC
通讯作者：
Detrano, RC
影响因子：
5.8
作者：
Huang, Yun;Bi, Yufang;Ning, Guang
通讯作者：
Ning, Guang
影响因子：
1.3
作者：
Mao, Song S.;Pal, Raveen S.;Budoff, Matthew Jay
通讯作者：
Budoff, Matthew Jay
影响因子：
16.2
作者：
Gerstein, HC;Anand, S;Yusuf, S
通讯作者：
Yusuf, S