DAUGHTERLESS, A DROSOPHILA GENE ESSENTIAL FOR BOTH NEUROGENESIS AND SEX DETERMINATION, HAS SEQUENCE SIMILARITIES TO MYC AND THE ACHAETE-SCUTE COMPLEX
DAUGHTERLESS, A DROSOPHILA GENE ESSENTIAL FOR BOTH NEUROGENESIS AND SEX DETERMINATION, HAS SEQUENCE SIMILARITIES TO MYC AND THE ACHAETE-SCUTE COMPLEX
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DOI：
10.1016/0092-8674(88)90250-4
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发表时间：
1988-12-23
期刊：
影响因子：
64.5
通讯作者：
JAN, YN
中科院分区：
文献类型：
--
作者：
CAUDY, M;VASSIN, H;JAN, YN
在果蝇胚胎发育过程中，无女儿（Daughterless，da）具有多种功能：母体da活性是正确性别决定所必需的，合子da活性是外周神经系统形成所必需的。我们克隆了含有da的区域，发现5个隐性致死da突变映射到一个转录单位。该转录单位的预测蛋白质产物与癌基因myc、与基因MyoD1（其参与成肌细胞决定）和与果蝇无毛鳞片复合物（其参与神经元前体决定）具有序列相似性。DA作为一个基因控制细胞决定在多个发育途径的作用进行了讨论。
Daughterless (da) has multiple functions in Drosophila embryonic development: maternal da activity is necessary for proper sex determination, and zygotic da activity is neccessary for formation of the peripheral nervous system. We have cloned the region containing da and have found that five recessive lethal da mutations map to a single transcription unit. A predicted protein product of this transcription unit has sequence similarities with the oncogene myc, with the gene MyoD1, which is involved in myoblast determination, and with the Drosophila achaete-scute complex, which is involved in neuronal precursor determination. The role of da as a gene controlling cell determination in multiple developmental pathways is discussed.