Expression of RAD51 and Its Clinical Impact in Oral Squamous Cell Carcinoma
Expression of RAD51 and Its Clinical Impact in Oral Squamous Cell Carcinoma
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DOI：
10.1155/2020/1827676
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发表时间：
2020-03-03
影响因子：
3.2
通讯作者：
Liu, Weiwei
中科院分区：
文献类型：
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作者：
Li, Yuyang;Li, Jia;Liu, Weiwei
目的.检测口腔鳞状细胞癌（OSCC）组织中RAD51的表达，分析其与病理分级、临床分期及淋巴结转移的关系。方法.本研究收集了74例口腔鳞状细胞癌样本、15例正常粘膜组织和11例正常皮肤组织样本。采用免疫组织化学方法研究了RAD51的表达。随访用于评估每个患者的预后。我们比较了口腔粘膜上皮细胞（OMEC），角质形成细胞，舌鳞状细胞癌细胞（TSCC）的蛋白质印迹分析的RAD 51的表达。结果RAD51在肿瘤细胞中的表达高于正常粘膜组织。此外，RAD51表达与肿瘤分化程度有关（P
Purpose. To examine the expression of RAD51 in oral squamous cell carcinoma (OSCC) and analyze its connection with pathological grade, clinical stage, and lymphatic metastasis potential. Methods. For this study, 74 OSCC samples, 15 normal mucosa tissues, and 11 normal skin tissue samples were collected. RAD51 expression was investigated using immunohistochemistry. A follow-up visit was used to assess the prognosis of each patient. We compared RAD51 expression in oral mucosa epithelial cells (OMECs), keratinocytes, and tongue squamous cell carcinoma cells (TSCCs) by Western blot analysis. Results. RAD51 expression was higher in tumor cells than in normal mucosal tissues. In addition, RAD51 expression was associated with higher tumor differentiation (P