Simulation Study on the Feasibility of Current-mode SPECT for B-10 Concentration Estimation in Boron Neutron Capture Therapy
Simulation Study on the Feasibility of Current-mode SPECT for B-10 Concentration Estimation in Boron Neutron Capture Therapy
复制标题
硼中子俘获治疗中电流模式SPECT估算B-10浓度可行性的模拟研究
DOI：
10.1088/1748-0221/14/02/c02002
复制
发表时间：
2019
影响因子：
1.3
通讯作者：
F. Funama
中科院分区：
文献类型：
--
作者：
I. Kanno;D. Nishimatsu;F. Funama
硼中子俘获治疗（BNCT）是一种很有前途的治疗侵袭性肿瘤的方法。BNCT利用10 B的中子俘获反应产生的α粒子和7 Li的能量沉积。10 B显像是BNCT的难点之一。7 Li发射的能量为0.478 MeV的伽马射线可用于此目的。然而，由于2.22MeV γ射线与1H中子反应产生的高γ射线背景，γ射线的光子计数非常困难。为了克服这个困难，作者提出了一种方法来测量伽马射线作为电流的“transXend”探测器，这是他们发明的能量分辨X射线计算机断层扫描。本文通过模拟研究，探讨了10 B分布在带肿瘤区的水模体中成像的可行性。为了建立transXend探测器中伽马射线感应电流与10 B浓度之间的关系，应考虑体模对伽马射线的衰减。为此，采用了神经网络。结果表明，与用于神经网络的训练数据吻合良好。
Boron neutron caputure therapy (BNCT) is a promising treatment for invasive tumors. The BNCT utilizes the energy deposition by alpha particle and 7 Li created by the neutron capture reaction of 10 B. One of the problem of BNCT is the imaging of 10 B distribution during the treatment. The gamma rays with the energy of 0.478 MeV emitted by 7 Li can be exploited for this purpose. The photon counting of the gamma rays, however, is very difficult due to the high gamma ray background caused by 2.22 MeV gamma rays originated by the neutron reactions with 1 H. To overcome this difficulty, the authors propose a method to measure gamma rays as electric current by a" transXend" detector, which had been invented by them for energy-resolved X-ray computed tomography. In this paper, the feasibility study on 10 B distribution imaging in a water phantom with a tumor region is shown by simulation studies. For establishing the relationship between electric currents induced in the transXend detector by gamma rays and 10 B concentration, the attenuation of gamma rays by the phantom should be taken into account. For this purpose, a neural network was employed. The results showed good agreement with the training data used for the neural network.