Social Facilitation of d-Amphetamine Self-Administration in Rats
Social Facilitation of d-Amphetamine Self-Administration in Rats
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DOI：
10.1037/a0024682
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发表时间：
2011-12-01
影响因子：
2.3
通讯作者：
Bardo, Michael T.
中科院分区：
文献类型：
--
作者：
Gipson, Cassandra D.;Yates, Justin R.;Bardo, Michael T.
社会影响和药物滥用之间的联系早已在人类身上确立。然而，药物滥用的临床前动物模型直到最近才开始考虑社会影响的作用。由于社会因素影响人类药物使用的开始和维持，因此在临床前动物模型中纳入这些因素非常重要。目前的研究探讨了社会合作伙伴的存在对响应蔗糖丸在各种动机条件下的影响，以及对d-苯丙胺（AMPH）自我管理。训练大鼠对蔗糖或AMPH（0.01或0.1 mg/kg/输注单位剂量）进行杠杆按压。反应稳定后，一个新的同性同种提出了一个明确的分隔器分隔在相邻的隔间，并响应蔗糖或AMPH奖励进行了测量。使大鼠重新稳定，随后给予额外的伴侣介绍。社交伴侣的存在仅在与0.1 mg/kg/输注单位剂量的AMPH第一次配对期间增加了反应，而在获得0.01 mg/kg/输注单位剂量的第一次配对期间观察到了反应抑制。在自由饲料条件下，蔗糖颗粒反应的抑制观察到的社会合作伙伴的存在下，但这种影响下的食物限制减弱。与此相反，结果表明社会促进AMPH自我管理在一个高的单位剂量，从而扩大社会因素的影响，操作性条件反射任务。这种社会促进模式可能具有重要的意义，作为社会对药物滥用的影响的临床前模型。
The link between social influence and drug abuse has long been established in humans. However, preclinical animal models of drug abuse have only recently begun to consider the role of social influence. Since social factors influence the initiation and maintenance of drug use in humans, it is important to include these factors in preclinical animal models. The current study examined the effects of the presence of a social partner on responding for sucrose pellets under various motivational conditions, as well as on d-amphetamine (AMPH) self-administration. Rats were trained to lever press for either sucrose or AMPH (0.01 or 0.1 mg/kg/infusion unit dose). Following response stability, a novel same-sex conspecific was presented in an adjacent compartment separated by a clear divider, and responding for sucrose or AMPH reward was measured. Rats were allowed to restabilize, and subsequently given an additional partner presentation. Presence of the social partner increased responding only during the first pairing with the AMPH 0.1 mg/kg/infusion unit dose, whereas inhibition of responding was observed during the first pairing during access to the 0.01 mg/kg/infusion unit dose. Under free feed conditions, inhibition of sucrose pellet responding was observed in the presence of the social partner, but this effect was attenuated under food restriction. In contrast, the results demonstrate social facilitation of AMPH self-administration at a high unit dose, thus extending the influence of social factors to an operant conditioning task. This model of social facilitation may have important implications as a preclinical model of social influence on drug abuse.