Clinical and microbiological characteristics of Nocardiosis including those caused by emerging Nocardia species in Taiwan, 1998-2008
Clinical and microbiological characteristics of Nocardiosis including those caused by emerging Nocardia species in Taiwan, 1998-2008
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DOI：
10.1111/j.1469-0691.2009.02950.x
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发表时间：
2010-07-01
影响因子：
14.2
通讯作者：
Hsueh, P. -R.
中科院分区：
文献类型：
--
作者：
Tan, C. -K.;Lai, C. -C.;Hsueh, P. -R.
诺卡氏菌属迅速扩大，不同地理位置的种类分布不同。我们回顾性分析了1998年1月至2008年6月间台大医院细菌实验室的实验室记录，以确定诺卡氏菌病患者。在研究期间，164株诺卡氏菌。但只有113例患者有诺卡氏菌感染。巴西诺卡氏菌（Nocardia brasiliensis，n = 54）是最常见的病原菌，其次是N. asteroides（n = 36），N. farcinica，N. flavorosea，N. otitidiscaviarum（n = 3），N. nova（n = 3）、新单胞菌N. beijingensis（n = 2）和N. puris，新单胞菌N. jinanensis和N. Takedensis。感染类型以皮肤感染（56.6%）、肺部感染（33.6%）和播散性感染（7.1%）为主。88例患者接受了含磺胺类抗生素治疗，100例有可用结局数据的患者中有8例在诺卡氏菌病发作期间死亡。总之，诺卡氏菌病的临床和微生物学表现因不同的诺卡氏菌而异。准确识别物种对诊断至关重要。
P>The genus of Nocardia is rapidly expanding and the species distribution varies with different geographical locations. We retrospectively reviewed the laboratory records of the bacteriology laboratory at National Taiwan University Hospital from January 1998 to June 2008 to identify patients with nocardiosis. During the study period, 164 isolates of Nocardia spp. were identified from 134 patients but only 113 patients had Nocardia infection. Nocardia brasiliensis (n = 54) was the most common pathogen, followed by N. asteroides (n = 36), N. farcinica (n = 7), N. flavorosea (n = 4), N. otitidiscaviarum (n = 3), N. nova (n = 3), N. beijingensis (n = 2) and one each of N. puris, N. jinanensis and N. takedensis. The major types of infection were cutaneous infection (56.6%), pulmonary infection (33.6%) and disseminated infection (7.1%). Eighty-eight patients received sulfonamide-containing antibiotic and eight of 100 patients with available data on outcomes died during the episode of nocardiosis. In conclusion, the clinical and microbiological manifestations of Nocardiosis vary with the different Nocardia species. Accurate identification of the species is crucial to make the diagnosis.