Micro-computed tomography imaging of composite nanoparticle distribution in the lung.
Micro-computed tomography imaging of composite nanoparticle distribution in the lung.
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DOI：
10.1016/j.ijpharm.2012.09.036
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发表时间：
2012-12
影响因子：
5.8
通讯作者：
M. Beck-Broichsitter;J. Gauss;C. Schweiger;Susanne Roesler;T. Schmehl;M. Kampschulte;A. Langheinrich;W. Seeger
中科院分区：
文献类型：
--
作者：
M. Beck-Broichsitter;J. Gauss;C. Schweiger;Susanne Roesler;T. Schmehl;M. Kampschulte;A. Langheinrich;W. Seeger
纳米医学在治疗严重疾病方面具有巨大的潜力。了解纳米颗粒在靶部位的行为将有助于开发用于呼吸医学的专用工具。在这里，我们感兴趣的是微计算机断层扫描（μCT）成像监测聚合纳米颗粒肺分布的潜力。对复合纳米颗粒的理化性质、形貌和组成进行了分析。μCT观察复合纳米颗粒在急性肺损伤模型中的肺分布。所采用的复合纳米颗粒由涂有一层胶质氧化铁的薄壳的聚苯乙烯内核组成。光镜观察，颗粒主要位于肺间质，与肺细胞相关。μCT检查导管（线状）和呼吸道（腺状）x射线衰减增强。综上所述，多功能纳米颗粒将促进呼吸医学中新型治疗和诊断工具的发展。
Nanomedicine comprises a significant potential to approach the therapy of severe diseases. Knowledge of nanoparticle behavior at the target site would contribute to the development of specialized tools for respiratory medicine. Here, we were interested in the potential of micro-computed tomography (μCT) imaging to monitor the pulmonary distribution of polymeric nanoparticles.Composite nanoparticles were analyzed for physicochemical properties, morphology and composition. μCT was employed to visualize the pulmonary distribution of composite nanoparticles in anex vivolung model.Employed composite nanoparticles were composed of poly(styrene) cores coated by a thin shell of colloidal iron oxide. Particles were mainly located in the interstitial space and associated with pulmonary cells, as observed by light microscopy. μCT detected enhanced X-ray opacities in the conducting (linear pattern) and respiratory airways (aciniform X-ray attenuations).In conclusion, multifunctional nanoparticles will prompt the development of novel therapeutic and diagnostic tools in respiratory medicine.