Static and Dynamic Functional Connectivity Alterations in Alzheimer's Disease and Neuropsychiatric Diseases
Static and Dynamic Functional Connectivity Alterations in Alzheimer's Disease and Neuropsychiatric Diseases
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DOI：
10.1089/brain.2022.0044
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发表时间：
2023-06-01
影响因子：
3.4
通讯作者：
Yamashita，Ken-ichiro
中科院分区：
文献类型：
--
作者：
Matsui，Teppei;Yamashita，Ken-ichiro
背景：迄今为止，许多研究已经证明了阿尔茨海默病（AD）和其他神经精神疾病的静息脑活动的各种改变。特别是，静息状态网络（RSN）中的功能连接（FC）的疾病相关改变已被记录。RSN中FC的改变不仅有助于解释疾病的表型，而且有助于疾病的诊断。最近，一些研究提出了动态的休息脑活动作为一个有用的标记，用于检测改变RSNs相关的AD和其他diseases.Objectives：在这篇文章中，我们回顾了最近的研究探索AD和其他神经精神疾病的静态和动态功能连接的改变。然后，我们讨论了如何利用和解释动态FC研究静息脑活动在diseases.Results：在以前的研究，它专注于FC计算使用整个功能磁共振成像扫描（静态FC），较新的研究集中在FC的扫描（动态FC）内的时间动态，以提供更敏感的措施来表征RSNs。然而，尽管越来越受欢迎的动态FC，几个动态FC的统计调查警告说，在常用的分析动态FC需要仔细interpretation.Conclusions：虽然静态和动态FC可能是一个有用的工具来检测改变RSN的患者受AD和其他神经精神疾病，解释改变动态FC的患者需要特别照顾。Impact statementWe审查最近的研究静态和动态功能连接（dFC）在阿尔茨海默病和讨论的解释dFC。
Background:To date, numerous studies have documented various alterations in resting brain activity in Alzheimer's disease (AD) and other neuropsychiatric diseases. In particular, disease-related alterations of functional connectivity (FC) in the resting state networks (RSN) have been documented. Altered FC in RSN is useful not only for interpreting the phenotype of diseases but also for diagnosing the diseases. More recently, several studies proposed the dynamics of resting-brain activity as a useful marker for detecting altered RSNs related to AD and other diseases.Objectives:In this article, we review recent studies exploring alterations of static and dynamic functional connectivity in AD and other neuropsychiatric diseases. We then discuss how to utilize and interpret dynamics of FC for studying resting brain activity in diseases.Results:In contrast to previous studies, which focused on FC calculated using an entire fMRI scan (static FC), newer studies focused on the temporal dynamics of FC within the scan (dynamic FC) to provide more sensitive measures to characterize RSNs. However, despite the increasing popularity of dynamic FC, several statistical investigations of dynamic FC cautioned that the results obtained in commonly used analyses for dynamic FC require careful interpretation.Conclusions:Although static and dynamic FC are likely to be a useful tool to detect altered RSN in patients affected by AD and other neuropsychiatric disorders, interpretation of altered dynamic FC in patients require special care.Impact statementWe review recent studies of static and dynamic functional connectivity (dFC) in Alzheimer's disease and discuss interpretation of dFC.