Neuroprotection mediated by natural products and their chemical derivatives.

Neuroprotection mediated by natural products and their chemical derivatives.
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天然产物及其化学衍生物介导的神经保护

DOI:
10.4103/1673-5374.282240
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发表时间:
2020-11
影响因子:
6.1
通讯作者:
Fei Z
Fei Z
中科院分区:
医学2区
文献类型:
--
作者:
Fei F;Su N;Li X;Fei Z

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神经元损伤可导致各种疾病,例如神经变性疾病、中风、创伤、局部缺血,更具体地,青光眼和视神经炎。调节神经元死亡的细胞机制包括钙内流和钙超载、兴奋性氨基酸释放、氧化应激、炎症和小胶质细胞活化。利用天然产物开发有效的神经保护药物已引起人们的重视。本文综述了从人参、茶树、大豆等植物中提取的天然产物及其化学衍生物的神经保护作用。它们的抗氧化和抗炎作用和它们的细胞凋亡和小胶质细胞活化的抑制进行了评估。这将为开发治疗神经退行性疾病的新药和策略提供新的方向。
Neuronal injuries can lead to various diseases such as neurodegenerative diseases, stroke, trauma, ischemia and, more specifically, glaucoma and optic neuritis. The cellular mechanisms that regulate neuronal death include calcium influx and calcium overload, excitatory amino acid release, oxidative stress, inflammation and microglial activation. Much attention has been paid to the effective prevention and treatment of neuroprotective drugs by natural products. This review summarizes the neuroprotective aspects of natural products, extracted from Panax ginseng, Camellia sinensis, soy and some other plants, and some of their chemical derivatives. Their antioxidative and anti-inflammatory action and their inhibition of apoptosis and microglial activation are assessed. This will provide new directions for the development of novel drugs and strategies to treat neurodegenerative diseases.
钙蛋白酶在神经元死亡中的调节作用
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