The transmural activation sequence in porcine and canine left ventricle is markedly different during long-duration ventricular fibrillation
The transmural activation sequence in porcine and canine left ventricle is markedly different during long-duration ventricular fibrillation
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DOI：
10.1111/j.1540-8167.2007.00963.x
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发表时间：
2007-12-01
影响因子：
2.7
通讯作者：
Ideker, Raymond E.
中科院分区：
文献类型：
--
作者：
Allison, J. Scott;Qin, Hao;Ideker, Raymond E.
心室颤动的透壁激活序列。背景：人类的跨壁浦肯野和心脏离子通道分布与狗比猪更相似。猪的浦肯野网络是透壁的，但狗的浦肯野网络仅限于心内膜。鉴于这些差异，人们对长时室颤 (LDVF) 期间的壁内激活知之甚少。我们测试了这样的假设：狗和猪的窦性心律 (SR) 和 LDVF 的跨壁激活序列相似，但物种之间不同。方法和结果：在六只猪和七只狗中，在整个左心室放置 50-60 个插入针（六个电极，间距 2 毫米）。单极记录的 LDVF 时间超过 10 分钟。通过沿着每根针连接激活，将 SR 和 LDVF 激活时间分组为波。确定每个波的起源（最早激活）和传播方向。对于 SR 和 1 至 10 分钟的 LDVF，狗的平均波起源明显多于猪的心内膜。在狗中，LDVF 和 SR 的主要传播方向是心内膜到心外膜，但在猪中，两个方向相反或相等。猪的心外膜激活率最快，而狗的心内膜激活率梯度增加，随着LDVF在狗而非猪中的进展，心内膜到心外膜的激活率梯度不断增加。结论：SR和LDVF的跨壁激活序列在猪和狗之间显着不同。这些差异可能与浦肯野纤维和离子通道分布的差异有关，并且考虑到与人类的相似性，狗是研究 LDVF 期间激活序列的更好模型。
Transmural Activation Sequence in Ventricular Fibrillation. Background: Humans are more similar in transmural Purkinje and cardiac ion channel distributions to dogs than pigs. The Purkinje network in pigs is transmural but confined to the endocardium in dogs. Little is known about intramural activation during long-duration ventricular fibrillation (LDVF) given these differences. We tested the hypothesis that the transmural activation sequence is similar in sinus rhythm (SR) and LDVF in dogs as well as pigs, but different between species.Methods and Results: In six pigs and seven dogs, 50-60 plunge needles (six electrodes, 2-mm spacing) were placed throughout the left ventricle. Unipolar recordings were made for >10 minutes of LDVF. SR and LDVF activation times were grouped into waves by linking activations along each needle. Origin (earliest activation) and propagation direction were determined for each wave. The mean wave origin was significantly more endocardial in dogs than pigs for SR and 1 through 10 minutes of LDVF. Predominant propagation direction in LDVF and SR was endocardial to epicardial in dogs, but the opposite or equal in both directions in pigs. Fastest activation rate was epicardial in pigs, but endocardial in dogs with an increasing endocardial-to-epicardial activation rate gradient as LDVF progressed in dogs but not pigs.Conclusions: The transmural activation sequence in SR and LDVF is markedly different between pigs and dogs. These differences may be related to differences in Purkinje fiber and ion channel distributions and suggest that dogs are a better model for investigating activation sequences during LDVF, given the similarities with humans.