MgSO4 prevents left ventricular dysfunction in an animal model of preeclampsia
MgSO4 prevents left ventricular dysfunction in an animal model of preeclampsia
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DOI：
10.1016/j.ajog.2006.02.049
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发表时间：
2006-11-01
影响因子：
9.8
通讯作者：
Standley, Cynthia A.
中科院分区：
文献类型：
--
作者：
Coates, Brian J.;Broderick, Tom L.;Standley, Cynthia A.
目的：我们假设，心脏功能将减少在妊娠大鼠模型的先兆子痫诱导的L-NAME，NOS抑制剂，并逆转与硫酸镁prophylaxy.Study设计：雌性Sprague-Dawley大鼠饲养在内部。在妊娠第17天，将大鼠麻醉，并植入渗透微型泵以连续递送盐水、L-NAME或L-NAME和MgSO 4。结果：与生理盐水对照组相比，L-NAME组孕鼠出现明显的高血压（P < 0.05）; L-NAME组大鼠心输出量和心脏作功明显低于对照组（P < 0.05）。结论：在L-NAME诱导的钳夹前期动物模型中，心功能受到抑制。MgSO 4防止了心功能的降低，并且在先兆子痫中明显有益于保持正常的心功能。(c)2006 Mosby，Inc. All rights reserved.
Objective: We hypothesized that cardiac function would be reduced in a pregnant rat model of preeclampsia induced by L-NAME, a NOS inhibitor, and be reversed with magnesium sulfate prophylaxis.Study design: Female Sprague-Dawley rats were bred in-house. On gestational day 17, rats were anesthetized and osmotic minipunips were implanted to continuously deliver saline, L-NAME, or L-NAME and MgSO4. On gestational day 21, hearts were isolated and perfused in the working mode using Krebs Henseleit buffer.Results: Pregnant rats treated with L-NAME displayed significant hypertension compared to the saline-treated controls (P < 0.05). Moreover, cardiac output and cardiac work were significantly reduced in the L-NAME-treated rats compared to controls (P < 0.05). In the L-NAME-treated rats given MgSO4, cardiac function remained normal.Conclusion: Cardiac function is depressed in an animal model of precclampsia induced by L-NAME infusion. MgSO4 prevented the reduction in cardiac function and is clearly beneficial in preserving normal heart function in preeclampsia. (c) 2006 Mosby, Inc. All rights reserved.