Venezuelan equine encephalitis virus infection of spiny rats.
Venezuelan equine encephalitis virus infection of spiny rats.
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DOI：
10.3201/eid1105.041251
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发表时间：
2005-05
影响因子：
11.8
通讯作者：
Weaver SC
中科院分区：
文献类型：
--
作者：
Carrara AS;Gonzales G;Ferro C;Tamayo M;Aronson J;Paessler S;Anishchenko M;Boshell J;Weaver SC
委内瑞拉马脑炎病毒（VEEV）的地方动物毒株在墨西哥、中美洲和南美洲的森林生境中传播，据信棘鼠（Proechimys spp.）是几个疫源地的主要宿主。为了更好地了解宿主-病原体的相互作用和许多宿主的疾病抗性特征，我们使用同域和异域病毒株对在哥伦比亚一个地方流行性VEEV疫区收集的chrysaeolus Proechimys F1后代进行了实验感染。所有动物均呈病毒血症，平均峰值滴度为3.3 log10 PFU/mL，血清抗体滴度为1:20 ~ 1:640，持续15个月。未观察到疾病迹象，包括脑内注射后。这些动物缺乏可检测到的疾病和有限的组织病理学病变，与在其他实验室啮齿动物和人类中观察到的严重疾病和组织病理学结果形成鲜明对比，并支持它们作为与VEEV具有长期共同进化关系的宿主的作用。
Enzootic strains of Venezuelan equine encephalitis virus (VEEV) circulate in forested habitats of Mexico, Central, and South America, and spiny rats (Proechimys spp.) are believed to be the principal reservoir hosts in several foci. To better understand the host-pathogen interactions and resistance to disease characteristic of many reservoir hosts, we performed experimental infections of F1 progeny from Proechimys chrysaeolus collected at a Colombian enzootic VEEV focus using sympatric and allopatric virus strains. All animals became viremic with a mean peak titer of 3.3 log10 PFU/mL, and all seroconverted with antibody titers from 1:20 to 1:640, which persisted up to 15 months. No signs of disease were observed, including after intracerebral injections. The lack of detectable disease and limited histopathologic lesions in these animals contrast dramatically with the severe disease and histopathologic findings observed in other laboratory rodents and humans, and support their role as reservoir hosts with a long-term coevolutionary relationship to VEEV.