Neural circuit-dependent odor adaptation in C-elegans is regulated by the Ras-MAPK pathway
Neural circuit-dependent odor adaptation in C-elegans is regulated by the Ras-MAPK pathway
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DOI：
10.1111/j.1365-2443.2005.00856.x
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发表时间：
2005-06-01
期刊：
影响因子：
2.1
通讯作者：
Iino, Y
中科院分区：
文献类型：
--
作者：
Hirotsu, T;Iino, Y
在嗅觉神经元中调节气味适应的分子机制在各种动物物种中都有很好的记录。然而，依赖于神经回路的适应类型大多未被探索。我们在这里报告说，Ras-MAPK途径是必不可少的，这种类型的气味适应，称为早期适应，在C。优美的早期适应需要一对AIY中间神经元，它们接收来自嗅觉神经元的突触输入。Ras-MAPK通路的突变体在早期适应中显示出缺陷。持续暴露于气味剂不仅在嗅觉神经元中，而且在AIY中间神经元中引起MAP激酶的激活。虽然嗅觉神经元中的Ras-MAPK通路的活性对于气味感知是重要的，但其在AIY中间神经元中的活性对于气味适应是重要的。因此，我们的研究结果揭示了Ras-MAPK通路在感觉加工中的双重作用，在神经系统中的C。优雅的。
The molecular machinery that mediates odor adaptation in the olfactory neurons is well documented in various animal species. However, types of adaptation that depend on neural circuits are mostly unexplored. We report here that the Ras-MAPK pathway is essential for such a type of odor adaptation, called early adaptation, in C. elegans. Early adaptation requires a pair of AIY interneurons, which receive synaptic inputs from olfactory neurons. Mutants of the Ras-MAPK pathway show defects in early adaptation. Continued exposure to an odorant causes activation of MAP kinase not only in the olfactory neurons, but also in the AIY interneurons. While activity of the Ras-MAPK pathway in the olfactory neurons is important for odor perception, its activity in the AIY interneurons is important for odor adaptation. Our results thus reveal a dual role of the Ras-MAPK pathway in sensory processing in the nervous system of C. elegans.