INCIDENTAL AND INTENTIONAL RECALL IN PARKINSONS-DISEASE - AN ACCOUNT BASED ON DIMINISHED ATTENTIONAL RESOURCES
INCIDENTAL AND INTENTIONAL RECALL IN PARKINSONS-DISEASE - AN ACCOUNT BASED ON DIMINISHED ATTENTIONAL RESOURCES
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DOI：
10.1080/01688639308402591
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发表时间：
1993-09-01
影响因子：
2.2
通讯作者：
SAGAR, HJ
中科院分区：
文献类型：
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作者：
COOPER, JA;SAGAR, HJ
在65例帕金森病（PD）患者的条件下，可用的注意力资源被操纵的次要任务的要求，检查了常见的物体和它们的空间位置的回忆。PD患者在项目回忆受损，特别是在有意学习条件下，但在空间位置的回忆未受损。这些发现在新诊断、未经治疗的病例以及平均患病9.6年的患者中相似。测试性能没有改善左旋多巴治疗，尽管它有利于运动控制，并没有受到抗胆碱能药物的损害。项目回忆与其他记忆措施（特别是工作记忆的任务）显着相关，但只有微弱的身体残疾和传统的额叶措施的指数。相比之下，空间回忆，与记忆商，但没有其他认知措施和抑郁症和疾病的持续时间没有显着相关的性能上的回忆任务。这些结果归因于PD中注意力资源的不足，这对努力要求最高的任务和条件的表现影响最明显。
The recall of common objects and their spatial location was examined in 65 patients with Parkinson's disease (PD) under conditions in which available attentional resources were manipulated by secondary task demands. PD patients were impaired at item recall particularly under intentional learning conditions but were unimpaired at recall of spatial location. These findings were similar in newly diagnosed, untreated cases as well as patients who had suffered with the disease for an average of 9.6 years. Test performance was not improved by levodopa therapy, despite it benefiting motor control, and was not impaired by anticholinergic medication. Item recall correlated significantly with other memory measures (particularly tasks of working memory) but only weakly with indices of physical disability and traditional frontal-lobe measures. Spatial recall, by contrast, correlated with memory quotient but no other cognitive measure and depression and disease duration failed to correlate significantly with performance on either recall task. These results are attributed to a deficit in attentional resources in PD that impairs performance most markedly for tasks and conditions that make the greatest demands upon effort.