Traumatic stress symptoms in family caregivers of patients with acute leukaemia: protocol for a multisite mixed methods, longitudinal, observational study.
Traumatic stress symptoms in family caregivers of patients with acute leukaemia: protocol for a multisite mixed methods, longitudinal, observational study.
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DOI：
10.1136/bmjopen-2022-065422
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发表时间：
2022-11-04
期刊：
影响因子：
2.9
通讯作者：
Rodin, Gary
中科院分区：
文献类型：
--
作者：
Jibb, Lindsay A.;Nanos, Stephanie M.;Alexander, Sarah;Malfitano, Carmine;Rydall, Anne;Gupta, Sumit;Schimmer, Aaron D.;Zimmermann, Camilla;Hales, Sarah;Nissim, Rinat;Marmar, Charles;Schultebraucks, Katharina;Mah, Kenneth;Rodin, Gary
关键词：
癌症的诊断、进展或复发对家庭照顾者（FC）来说往往是高度创伤性的，但缺乏对痛苦的系统评估及其预防和治疗方法。急性白血病（AL）是一种危及生命的血液癌症，通常表现为急性，需要强化治疗，并伴有严重的身体症状。因此，创伤性应激可能是常见的FC AL患者。我们的目的是确定的患病率，严重程度，纵向过程和预测因子的FC AL患者在确诊后的第一年，并了解他们的生活经历的创伤性应激和感知的支持需求。这项双中心纵向、观察性、混合方法研究将从两个三级护理中心招募223名新诊断为AL的儿科或成人患者的成人FC。将从入组时以及入院接受初始治疗后1、3、6、9和12个月的自我报告问卷中收集定量数据。将使用描述性和机器学习方法分析定量数据，并使用多级建模（MLM）方法来确认机器学习结果。半结构化的定性访谈将在第3、6和12个月进行，并使用扎根理论方法进行分析。本研究由加拿大卫生研究院（CIHR编号PJT 173255）资助，并已获得安大略癌症研究伦理委员会（CTO项目ID：2104）的伦理批准。所产生的数据有可能为制定有针对性的创伤性心理干预措施提供信息，这是高危人群（如血液恶性肿瘤患者的FC）的公共卫生优先事项。一个综合的和研究结束时的知识翻译策略，涉及功能界别和其他利益相关者将被用来解释和传播研究结果。
The diagnosis, progression or recurrence of cancer is often highly traumatic for family caregivers (FCs), but systematic assessments of distress and approaches for its prevention and treatment are lacking. Acute leukaemia (AL) is a life-threatening cancer of the blood, which most often presents acutely, requires intensive treatment and is associated with severe physical symptoms. Consequently, traumatic stress may be common in the FCs of patients with AL. We aim to determine the prevalence, severity, longitudinal course and predictors of traumatic stress symptoms in FCs of patients with AL in the first year after diagnosis, and to understand their lived experience of traumatic stress and perceived support needs. This two-site longitudinal, observational, mixed methods study will recruit 223 adult FCs of paediatric or adult patients newly diagnosed with AL from two tertiary care centres. Quantitative data will be collected from self-report questionnaires at enrolment, and 1, 3, 6, 9 and 12 months after admission to hospital for initial treatment. Quantitative data will be analysed using descriptive and machine learning approaches and a multilevel modelling (MLM) approach will be used to confirm machine learning findings. Semi-structured qualitative interviews will be conducted at 3, 6 and 12 months and analysed using a grounded theory approach. This study is funded by the Canadian Institutes of Health Research (CIHR number PJT 173255) and has received ethical approval from the Ontario Cancer Research Ethics Board (CTO Project ID: 2104). The data generated have the potential to inform the development of targeted psychosocial interventions for traumatic stress, which is a public health priority for high-risk populations such as FCs of patients with haematological malignancies. An integrated and end-of-study knowledge translation strategy that involves FCs and other stakeholders will be used to interpret and disseminate study results.
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影响因子：
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作者：
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