Solvent-free, AlCl3-promoted tandem Friedel–Crafts reaction of arenes and aldehydes
Solvent-free, AlCl3-promoted tandem Friedel–Crafts reaction of arenes and aldehydes
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DOI：
10.1016/j.molcata.2006.03.060
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发表时间：
2006-08
影响因子：
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通讯作者：
Xiao Wang;Yikai Wang;D. Du;Jiaxi Xu
中科院分区：
文献类型：
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作者：
Xiao Wang;Yikai Wang;D. Du;Jiaxi Xu
研究了芳烃和醛在刘易斯酸催化下的串联Friedel-Crafts反应。在无溶剂条件下，芳香醛和脂肪醛与富电子芳烃在无水三氯化铝存在下发生Friedel-Crafts烷基化反应，得到1，1，1-三芳基/1，1-二芳基烷烃。并对串联反应的适用范围、局限性和机理进行了讨论。
Tandem Friedel–Crafts reaction of arenes and aldehydes under the catalysis of Lewis acid was investigated. Both aromatic and aliphatic aldehydes underwent a tandem Friedel–Crafts alkylation with electron-rich arenes to afford 1,1,1-triaryl/1,1-diarylalkanes in the presence of anhydrous aluminum chloride under solvent-free conditions. The scope, limitation, and mechanism of the tandem reaction were also discussed.