Diaphragmatic shear modulus at various submaximal inspiratory mouth pressure levels
Diaphragmatic shear modulus at various submaximal inspiratory mouth pressure levels
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DOI：
10.1016/j.resp.2018.03.009
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发表时间：
2018-06-01
影响因子：
2.3
通讯作者：
Suzuki, Yasuhiro
中科院分区：
文献类型：
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作者：
Chino, Kentaro;Ohya, Toshiyuki;Suzuki, Yasuhiro
本研究通过超声剪切波弹性成像评估了不同次最大吸气口压水平下隔膜的剪切模量。在14名健康男性受试者中，在静息呼吸期间呼气末和在次最大吸气任务中在最大吸气口压的15%、30%、45%、60%和75%下评估了血流剪切模量。剪切模量随口腔压力的增大而沿着增大，口腔压力与剪切模量的关系符合二次多项式回归方程（r（2）= 0.99 ± 0.01;所有受试者，r（2）>= 0.95），优于一次线性回归方程（r（2）= 0.94 ± 0.05; 8/14例受试者，r（2）>= 0.95）。二阶多项式回归方程中的二次回归系数在14名受试者中有10名为负值，表明二阶多项式回归方程向下开口。这些结果表明，弹性剪切模量随着吸气口压的增加而沿着增加，但当压力达到较高水平时，增加的速率减慢。
This study assessed the shear modulus of the diaphragm at various submaximal inspiratory mouth pressure levels by ultrasound shear wave elastography. In 14 healthy male subjects, diaphragmatic shear moduli were assessed at end expiration during resting breathing and at submaximal inspiratory tasks at 15, 30, 45, 60, and 75% of the maximal inspiratory mouth pressure. The shear modulus increased along with mouth pressure, and the mouth-pressure shear-modulus relationship fit the second-order polynomial regression equation (r(2) = 0.99 +/- 0.01; all subjects, r(2) >= 0.95) better than it did the simple linear regression equation (r(2) = 0.94 +/- 0.05; 8/14 subjects, r(2) >= 0.95). The second regression coefficient in the second-order polynomial equation was a negative value in 10 of 14 subjects, which indicates that the second-order polynomial regression equation opened downwards. These findings suggest that the diaphragmatic shear modulus increases along with inspiratory mouth pressure, but the rate of increase slows when the pressure reaches higher levels.