The Bst locus on mouse chromosome 16 is associated with age-related subretinal neovascularization
The Bst locus on mouse chromosome 16 is associated with age-related subretinal neovascularization
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DOI：
10.1073/pnas.040531597
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发表时间：
2000-02-29
影响因子：
11.1
通讯作者：
Chang, B
中科院分区：
文献类型：
--
作者：
Smith, RS;John, SWM;Chang, B
在发达国家，眼部新生血管是致盲的主要原因，并常常导致老年性黄斑变性患者视力迅速丧失。急性视力丧失通常是由于从脉络膜延伸到视网膜下空间的新血管出血所致。在这种情况下，视网膜下异常血管的生长被称为视网膜下新生血管（SRN）。黄斑变性和SRN的年龄相关动物模型尚未被描述。目前的SRN动物模型依赖于化学或物理刺激来启动视网膜下血管的生长。与年龄相关的人类黄斑变性伴SRN的基因尚未被确定。我们报告了Bst/+小鼠的血管生成表型，该表型与年龄相关，临床明显，类似于人类SRN。这代表了一种自发的、遗传决定的SRN模型，Bst/+小鼠提供了在不需要外源药物的情况下探索SRN分子机制的可能性。
Ocular neovascularization is the leading cause of blindness in developed countries and often causes rapid loss of vision in age-related macular degeneration. Acute visual loss is most often due to hemorrhage from new vessels that have extended from the choroid into the subretinal space. Growth of abnormal vessels beneath the retina in this condition is known as subretinal neovascularization (SRN). Age-related animal models of macular degeneration and SRN have not been described. Current animal models of SRN depend on chemical or physical stimuli to initiate growth of subretinal vessels. The genes responsible for age-related human macular degeneration with SRN have not been firmly identified. We report an angiogenic phenotype in Bst/+ mice that is age-related, clinically evident, and resembles human SRN. This represents a spontaneous, genetically determined model of SRN, Bst/+ mice offer the possibility of exploring the molecular mechanisms of SRN without the need for exogenous agents.