Stress-induced analgesia in humans: endogenous opioids and naloxone-reversible depression of pain reflexes.
Stress-induced analgesia in humans: endogenous opioids and naloxone-reversible depression of pain reflexes.
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人类压力引起的镇痛：内源性阿片类药物和纳洛酮可逆性抑制疼痛反射。
DOI：
10.1126/science.6261330
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发表时间：
1981
期刊：
影响因子：
56.9
通讯作者：
J. Cambier
中科院分区：
文献类型：
--
作者：
J. Willer;H. Dehen;J. Cambier
通过对下肢伤害性屈曲反射阈值的研究，研究了预期疼痛（伤害性足电击）引起的重复性应激的累积效应。伤害性反射的阈值随着应激的重复而进行性增加。这种作用被纳洛酮逆转，纳洛酮甚至产生痛觉过敏，因为观察到该阈值快速且显著降低，低于初始值。这些数据为内源性阿片类物质参与正常人应激镇痛现象提供了证据。
The cumulative effects of a repetitive stress induced by anticipation of pain (noxious foot shock) were studied on the threshold of a nociceptive flexion reflex of the lower limb. The threshold of the nociceptive reflex progressively increased with the repetition of the stress. This effect was reversed by naloxone, which even produced hyperalgesia, since a rapid and significant decrease in this threshold, below the initial values, was noted. Tha data provide evidence for involvement of endogenous opioids in the phenomenon of stress-induced analgesia in normal man.