Inactivation of gamma-aminobutyric acid aminotransferase by (S)-4-amino-4,5-dihydro-2-furancarboxylic acid does not proceed by the expected aromatization mechanism.
Inactivation of gamma-aminobutyric acid aminotransferase by (S)-4-amino-4,5-dihydro-2-furancarboxylic acid does not proceed by the expected aromatization mechanism.
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(S)-4-氨基-4,5-二氢-2-呋喃甲酸对γ-氨基丁酸转氨酶的灭活不会按照预期的芳构化机制进行。
DOI：
10.1016/j.bmcl.2003.09.065
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发表时间：
2004
影响因子：
2.7
通讯作者：
Silverman,RichardB
中科院分区：
文献类型：
--
作者：
Fu,Mengmeng;Silverman,RichardB
（S）-4-氨基-4，5-二氢-2-呋喃甲酸（SADFA）灭活吡哆醛5′-磷酸（PLP）依赖性γ-氨基丁酸氨基转移酶，得到吡哆胺5′-磷酸，而不是预期的SADFA-PLP芳构化产物。灭活似乎通过迈克尔加成/水解机制进行。
Inactivation of pyridoxal 5′-phosphate (PLP)-dependent γ-aminobutryic acid aminotransferase by (S)-4-amino-4,5-dihydro-2-furancarboxylic acid (SADFA) gives pyridoxamine 5′-phosphate, not the expected SADFA-PLP aromatization product. Inactivation appears to proceed by a Michael addition/hydrolysis mechanism instead.