Altered red blood cell distribution width in overweight adolescents and its association with markers of inflammation
Altered red blood cell distribution width in overweight adolescents and its association with markers of inflammation
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DOI：
10.1111/j.2047-6310.2012.00111.x
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发表时间：
2013-10-01
影响因子：
3.8
通讯作者：
Jung, C.
中科院分区：
文献类型：
--
作者：
Fujita, B.;Strodthoff, D.;Jung, C.
背景肥胖和代谢综合征是日益严重的问题。红细胞分布宽度(RDW)，即循环红细胞大小的变异性，已被证明在不同的临床环境中会发生变化。本研究旨在探讨RDW与青少年肥胖及饮食诱导肥胖(DIO)动物模型的关系。其中37人超重(体重指数为第90百分位数)。测定RDW、炎症标志物和干细胞因子(SCF)。在一项动物研究中，小鼠被喂以不同的饮食，持续15周。结果正常体重青少年RDW(13.070.09)与超重青少年RDW(13.39+/-0.10)差异有统计学意义(P=0.015)，而红细胞计数和红细胞压积差异无统计学意义。RDW与炎症指标呈正相关，与SCF呈负相关。在小鼠动物模型中，营养变化使RDW增加，而超重本身不改变RDW。结论超重时RDW升高，反映炎症状态。RDW可能是一种额外的、经济有效的指示炎症的工具。需要进一步的研究来了解营养和超重对RDW的不同影响。
BackgroundObesity and the metabolic syndrome are dramatically increasing problems. Red blood cell distribution width (RDW), the variability in size of circulating red blood cells, has been demonstrated to be altered in different clinical settings. This analysis aimed to investigate the relationship between RDW and obesity in adolescents and in an animal model of diet-induced obesity (DIO).MethodsSeventy-nine male adolescents (aged 13-17 years) were studied. Thirty-seven of them were overweight (body mass index90th percentile). RDW, markers of inflammation and stem cell factor (SCF) were determined. In an animal study, mice were fed with different diets for 15 weeks. RDW was determined using an animal blood count machine.ResultsRDW differed significantly between normal-weight adolescents (13.070.09) and overweight adolescents (13.39 +/- 0.10, P=0.015), whereas erythrocyte counts and haematocrit did not differ. RDW correlated to markers of inflammation and inversely to SCF. In the mice animal model, nutritional changes increased RDW, whereas overweight per se did not change RDW.ConclusionsRDW is elevated in overweight and reflects the inflammatory state. RDW potentially represents an additional and cost-effective tool to indicate inflammation. Future studies are needed to understand the differential influences of nutrition and overweight on RDW.