Effect of immune globulin on the prevention of experimental hepatitis C virus infection
Effect of immune globulin on the prevention of experimental hepatitis C virus infection
复制标题
DOI：
10.1093/infdis/173.4.822
复制
发表时间：
1996-04-01
影响因子：
6.4
通讯作者：
Carson, DA
中科院分区：
文献类型：
--
作者：
Krawczynski, K;Alter, MJ;Carson, DA
在实验感染的黑猩猩中，研究了暴露后预防对丙型肝炎病毒（HCV）感染的效果。其中2只在1小时后静脉注射抗HCV阴性免疫球蛋白（IGIV）或丙型肝炎免疫球蛋白（HCIG）治疗，另1只不治疗，3只动物在接种后数天内均检测到HCV感染，经HCV治疗的动物一旦被动转移的抗-HCV下降，HCV抗原（Ag）阳性肝细胞增加，随后再次出现抗-HCV；HCVAg的消失与急性肝炎的发展一致，注射IGIV和未注射IGIV的黑猩猩均出现急性丙型肝炎，肝酶活性在第59天达到峰值，而注射IGIV的黑猩猩则延迟到第146天。暴露后HCIG治疗明显延长了急性丙型肝炎的潜伏期，但没有预防或延迟HCV感染，IGIV对HCV感染的病程没有影响。
The efficacy of postexposure prophylaxis for the prevention of hepatitis C virus (HCV) infection was studied in experimentally infected chimpanzees, Three chimpanzees were inoculated with HCV: Two were treated 1 h later with anti-HCV-negative intravenous immune globulin (IGIV) or hepatitis C immune globulin (HCIG), and a third animal was not treated, HCV infection was detected in all 3 animals within a few days of inoculation, Once passively transferred anti-HCV declined in the HCIG-treated animal, there was an increase of HCV antigen (Ag)-positive hepatocytes followed by reappearance of anti-HCV; HCVAg disappeared concordant with the development of acute hepatitis, Acute hepatitis C developed in both the IGIV-treated and untreated chimpanzees, with peak liver enzyme activity on day 59, but was delayed in the HCIG-treated animal until day 146, Postexposure HCIG treatment markedly prolonged the incubation period of acute hepatitis C but did not prevent or delay HCV infection, IGIV had no effect on the course of HCV infection.