Diffusion tensor imaging and tractography of distal peripheral nerves at 3 T
Diffusion tensor imaging and tractography of distal peripheral nerves at 3 T
复制标题
DOI：
10.1016/j.clinph.2005.05.014
复制
发表时间：
2005-10-01
影响因子：
4.7
通讯作者：
Hari, R
中科院分区：
文献类型：
--
作者：
Hiltunen, J;Suortti, T;Hari, R
目标：我们研究了远端周围神经是否可以使用定量扩散张量成像（DTI）与3-T MRI扫描仪成像，并可视化使用tractraging.Methods：共6名健康受试者进行了研究。扩散量化与表观扩散系数（ADC）和分数各向异性（FA）地图，和主要的扩散率的方向可视化与彩色编码的方向图和tractragraphy.Results：我们提出的第一个DTI和tractragraphy结果的人类远端周围神经。首先分析上肢正中神经、尺神经和桡神经以及下肢胫神经和腓神经的走行，量化ADC和FA，然后使用纤维束成像进行可视化。纤维束成像能清晰地显示上下肢神经的三维走行，并能与周围肌肉组织和韧带可靠区分。结论：定量DTI和纤维束成像可用于远端周围神经的成像和可视化。重要性：DTI是一种定量方法，可以为神经损伤、卡压和再生的诊断和随访提供有用的信息。周围神经作为轮廓清晰的结构，也包含丰富的分支成不同直径的束，可以被用作“活的幻影”，用于测试和验证不同的纤维束成像方法。(c)2005年国际临床神经生理学联合会。由Elsevier爱尔兰有限公司出版。保留所有权利。
Objective: We studied whether distal peripheral nerves could be imaged using quantitative diffusion tensor imaging (DTI) with a 3-T MRI scanner, and visualized using tractography.Methods: Altogether 6 healthy subjects were studied. The diffusion was quantified with apparent diffusion coefficient (ADC) and fractional anisotropy (FA) maps, and the direction of main diffusivity was visualized with color-coded orientation maps and tractography.Results: We present the first DTI and tractography results of human distal peripheral nerves. The courses of median, ulnar, and radial nerves in the upper limb and of tibial and peroneal nerves in the lower limb were first analyzed quantifying ADC and FA, and then visualized in 31) with tractography. Tractography illustrated nicely the 3D courses of both upper and lower limb nerves which were reliably distinguished from the surrounding muscle tissue and ligaments.Conclusions: Quantitative DTI and tractography can be used to image and visualize distal peripheral nerves. Significance: DTI is a quantitative method that could provide useful information for the diagnosis and follow-up of nerve lesions, entrapments, and regeneration. Peripheral nerves as well-delineated structures also containing abundant branching into bundles of different diameters, could be used as 'living phantoms' for testing and validating different tractography methods. (c) 2005 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.