Engineered hybrid cardiac patches with multifunctional electronics for online monitoring and regulation of tissue function.
Engineered hybrid cardiac patches with multifunctional electronics for online monitoring and regulation of tissue function.
复制标题
具有多功能电子器件的工程混合心脏贴片，用于在线监测和调节组织功能。
DOI：
10.1038/nmat4590
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发表时间：
2016-06
期刊：
影响因子：
41.2
通讯作者：
Dvir T
中科院分区：
文献类型：
--
作者：
Feiner R;Engel L;Fleischer S;Malki M;Gal I;Shapira A;Shacham-Diamand Y;Dvir T
在治疗心肌梗死的心脏组织工程方法中，将心脏细胞接种在三维多孔支架内以产生功能性心脏补片。然而，目前的心脏贴片不允许在线监测和报告工程组织性能，并且不干扰递送用于贴片激活的信号或使其能够与宿主整合。在这里，我们报告了一种工程心脏贴片，它将心脏细胞与灵活的、独立的电子器件和3D纳米复合材料支架整合在一起。该贴片表现出强大的电子特性，能够记录细胞电活动和按需提供电刺激以同步细胞收缩。我们还表明，含有生物因子的电活性聚合物可以沉积在指定的电极上，按需在贴片微环境中释放药物。我们期望在心脏贴片内集成复杂的电子器件最终将提供心脏功能的治疗控制和调节。
In cardiac tissue engineering approaches to treat myocardial infarction, cardiac cells are seeded within three-dimensional porous scaffolds to create functional cardiac patches. However, current cardiac patches do not allow for online monitoring and reporting of engineered-tissue performance, and do not interfere to deliver signals for patch activation or to enable its integration with the host. Here, we report an engineered cardiac patch that integrates cardiac cells with flexible, free-standing electronics and a 3D nanocomposite scaffold. The patch exhibited robust electronic properties, enabling the recording of cellular electrical activities and the on-demand provision of electrical stimulation for synchronizing cell contraction. We also show that electroactive polymers containing biological factors can be deposited on designated electrodes to release drugs in the patch microenvironment on-demand. We expect that the integration of complex electronics within cardiac patches will eventually provide therapeutic control and regulation of cardiac function.