INSULIN-DEPENDENT METABOLISM OF BRANCHED-CHAIN AMINO-ACIDS IN OBESITY
INSULIN-DEPENDENT METABOLISM OF BRANCHED-CHAIN AMINO-ACIDS IN OBESITY
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DOI：
10.1016/0026-0495(84)90127-6
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发表时间：
1984-01-01
影响因子：
9.8
通讯作者：
PISI, E
中科院分区：
文献类型：
--
作者：
FORLANI, G;VANNINI, P;PISI, E
The effect of euglycemic hyperinsulinism on branched-chain amino acids (BCAA; valine, isoleucine and leucine) was evaluated in 5 obese subjects and 5 controls. A continuous i.v. insulin infusion raised plasma insulin to a steady-state level. An artificial endocrine pancreas that infused glucose was used to sustain euglycemia. Basal and steady-state insulin levels were significantly higher in the obese subjects than in the controls. The amount of glucose infused to maintain euglycemia and its ratio to steady-state insulin levels was significantly lower in the obese subjects, suggesting an impaired insulin action on glucose metabolism. Basal BCAA levels were similar in the 2 groups of subjects. During insulin infusion the decremental areas of BCAA below basal levels were significantly lower in the obese patients (63 .+-. 5 nmol/ml .cntdot. min vs. 143 .+-. 8 nmol/ml .cntdot. min, P < 0.001), as was the ratio of the decremental areas of BCAA to the incremental areas of insulin (1.11 .+-. 0.05 nmol/.mu.U vs. 3.30 .+-. 0.24 nmol/.mu.U, P < 0.001). Apparently, insulin resistance in obesity reduces hormonal effects on glucose as well as on BCAA metabolism.
