The differential killing of genes by inversions in prokaryotic genomes
The differential killing of genes by inversions in prokaryotic genomes
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DOI：
10.1007/s002390010248
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发表时间：
2001-12-01
影响因子：
3.9
通讯作者：
Cebrat, S
中科院分区：
文献类型：
--
作者：
Mackiewicz, P;Mackiewicz, D;Cebrat, S
我们已经详细阐述了一种方法，使我们能够估计的直系同源物的易位的方向，已经改变了，在染色体上的位置在染色体上的DNA链的领先或落后的作用。我们已经证明，基因从前导DNA链到滞后DNA链的位置转换的易位的相对数量低于将基因从原核基因组的滞后链转移到前导链的易位的数量。这个悖论可以通过假设更强的突变压力和倒位后的选择优先消除从前导DNA链转移到滞后DNA链的基因来解释。
We have elaborated a method which has allowed us to estimate the direction of translocation of orthologs which have changed, during the phylogeny, their positions on chromosome in respect to the leading or lagging role of DNA strands. We have shown that the relative number of translocations which have switched positions of genes from the leading to the lagging DNA strand is lower than the number of translocations which have transferred genes from the lagging strand to the leading strand of prokaryotic genomes. This paradox could be explained by assuming that the stronger mutation pressure and selection after inversion preferentially eliminate genes transferred from the leading to the lagging DNA strand.