Recent Advances in Nitrene/Alkyne Metathesis Cascade Reaction
Recent Advances in Nitrene/Alkyne Metathesis Cascade Reaction
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DOI：
10.6023/cjoc202109035
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Xu Xinfang
中科院分区：
文献类型：
--
作者：
Hong Kemiao;Huang Jingjing;Yao Minghan;Xu Xinfang
Catalytic nitrene transformations to N-containing molecules through direct C-N bond formation have experienced a dramatic development in the last decades. Although a variety of nitrene precursors have been disclosed under the corresponding catalytic conditions, which play a principal role in the synthesis of nitrogen-containing molecules with structural complexity, the types of nitrene transfer reactions mainly limited to the amination, aziridination, sulfimidation, and few others. In this area, reviews focused on different nitrene precursors, catalytic strategy (or metal catalysts), and challenging synthesis have been well-documented. In this review, the catalytic approaches of nitrene addition with alkynes, mainly nitrene/alkyne metathesis cascade reactions are outlined, which provide expeditious access to polycyclic, fused, and spiro N-heterocycles with structural diversity.
