[C-13]octanoic acid breath test for gastric emptying of solids: Accuracy, reproducibility, and comparison with scintigraphy
[C-13]octanoic acid breath test for gastric emptying of solids: Accuracy, reproducibility, and comparison with scintigraphy
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DOI：
10.1016/s0016-5085(97)70126-4
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发表时间：
1997-04-01
期刊：
影响因子：
29.4
通讯作者：
Nair, KS
中科院分区：
文献类型：
--
作者：
Choi, MG;Camilleri, M;Nair, KS
背景和目的：之前的研究表明，使用 C-13 进行呼气测试可以准确测量胃固体排空情况。因此，呼气测试半排空时间 (t(1/2)) 减去 66 分钟据称可以通过闪烁扫描准确估计 t(1/2)。本研究的目的是评估健康受试者呼气测试的准确性和可重复性。方法：15 名志愿者（8 名男性和 7 名女性；平均年龄，41 +/- 13 岁）接受同步闪烁扫描和 [C-13] 辛酸呼气测试。分别在 4 小时和 6 小时内每 15 分钟采集一次扫描和呼吸样本。呼吸测试在三周内重复三次。结果：闪烁扫描和呼吸测试的参数没有显着相关。两次测试之间的滞后期和 t(1/2) 差异很大（t(1/2) 范围为 -33.1 至 169.6；平均值为 48.0 分钟）。增加呼气测试“持续时间”（超过 4、5 或 6 小时的样本）会降低滞后期和 t(1/2) 的估计值。尽管在某些受试者中观察到的值存在很大差异，但重复呼气测试显示个体内具有高度的可重复性（平均变异系数，12%）。结论：[C-13]用于胃固体排空的辛酸呼气试验需要进一步验证才能替代闪烁扫描作为诊断试验，但它似乎对于个体间比较有用。
Background & Aims: Previous work suggested that a breath test using C-13 accurately measures gastric emptying of solids. Thus, breath test half emptying time (t(1/2)) minus 66 minutes was claimed to estimate accurately t(1/2) by scintigraphy. The aim of this study was to evaluate the accuracy and reproducibility of this breath test in healthy subjects. Methods: Fifteen volunteers (8 men and 7 women; mean age, 41 +/- 13 years) underwent simultaneous scintigraphy and [C-13]octanoic acid breath test. Scans and breath samples were obtained every 15 minutes for 4 and 6 hours, respectively. The breath test was repeated three times within a 3-week period. Results: Parameters from scintigraphy and breath test were not correlated significantly. Differences of lag phase and t(1/2) between the two tests were highly variable (range for t(1/2), -33.1 to 169.6; mean, 48.0 minutes). Increasing breath test ''duration'' (samples over 4, 5, or 6 hours) yielded decreasing estimates of the lag phase and t(1/2) Although widely different values were observed in some subjects, repeated breath tests showed a high degree of reproducibility within individuals (mean coefficient of variation, 12%). Conclusion: [C-13]Octanoic acid breath test for gastric emptying of solids requires further validation before it can substitute for scintigraphy as a diagnostic test, but it seems useful for intraindividual comparisons.