High-salt diet during pregnancy and angiotensin-related cardiac changes.
High-salt diet during pregnancy and angiotensin-related cardiac changes.
复制标题
妊娠期高盐饮食与血管紧张素相关的心脏变化
DOI：
10.1097/hjh.0b013e328337da8f
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发表时间：
2010-06
影响因子：
4.9
通讯作者：
Xu Z
中科院分区：
文献类型：
--
作者：
Ding Y;Lv J;Mao C;Zhang H;Wang A;Zhu L;Zhu H;Xu Z
目的高盐摄入已被证明与高血压有关，心血管疾病可能在胎儿起源中被编程。我们确定了怀孕期间高盐饮食对心脏发育的影响。方法观察妊娠期高盐摄入对胎儿心脏结构、细胞周期、肾素-血管紧张素系统（RAS）及心脏表观遗传学的影响。结果高盐暴露后胎儿心肌肌原纤维排列紊乱，线粒体嵴缺失，心肌细胞S期细胞增多，血浆血管紧张素II水平降低，心肌血管紧张素II水平升高。血管紧张素II增加胎儿心肌细胞的S期主要是通过AT 1受体机制。胎心AT 2受体mRNA和蛋白质未受影响，而AT 1受体蛋白、AT 1a和AT 1b mRNA增加。在胎儿心脏中发现与AT 1b受体相关的CpG位点存在DNA甲基化。心脏AT 1受体蛋白在成年后代也较高暴露于产前高盐。结论妊娠期高盐饮食与心肌细胞及肾素-血管紧张素系统的发育变化有关。
Objectives High-salt intake has been demonstrated in link to hypertension, and cardiovascular diseases could be programmed in fetal origins. We determined the influence of high-salt diet during pregnancy on the development of the heart. Methods Fetal cardiac structures, cell cycle, renin–angiotensin system (RAS), and epigenetic alternations in the heart following maternal high salt intake during pregnancy were examined. Results Following exposure to high salt, disorganized myofibrillae and mitochondria cristae loss were found in the fetus, S-phase for cardiac cells was enhanced, plasma angiotensin II decreased, and cardiac angiotensin II increased in the fetus. Angiotensin II-increased S-phase in the fetal cardiac cells was primarily via AT1 receptor mechanisms. AT2 receptor mRNA and protein in the fetal heart were not affected, whereas AT1 receptor protein, AT1a, and AT1b mRNA were increased. DNA methylation was found at the CpG sites that were related to AT1b receptors in the fetal heart. Cardiac AT1 receptor protein in the adult offspring was also higher following exposure to prenatal high salt. Conclusion The results suggest a relationship between high-salt diet in pregnancy and developmental changes of the cardiac cells and renin–angiotensin system.