Miniaturized phased-array ultrasound and photoacoustic endoscopic imaging system
Miniaturized phased-array ultrasound and photoacoustic endoscopic imaging system
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DOI：
10.1016/j.pacs.2019.100139
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发表时间：
2019-09-01
期刊：
影响因子：
7.9
通讯作者：
Mehrmohammadi, Mohammad
中科院分区：
文献类型：
--
作者：
Basij, Maryam;Yan, Yan;Mehrmohammadi, Mohammad
由于组织可及性、器械易用性和成像模式准确性等限制因素，早期妇科恶性肿瘤的可视化和检测对成像而言是一项挑战。在这项工作中，我们介绍了一种小型化的相控阵超声和光声内窥镜探头，它能够提供结构，功能和分子数据的表征妇科疾病。该探头由一个64单元超声相控阵换能器耦合到一个光纤光传输系统的共同注册的超声和光声成像。制造的US和PA成像内窥镜的直径为7.5 mm，允许通过宫颈管，从而与妇科组织（如宫颈管和子宫）密切接触。开发的内窥镜探头进行了测试，并在一套组织模仿幻影。US和PA分辨率进行了实验测量，使用200 μ m直径的电线，导致在明显的轴向和横向直径为289 μ m和299 μ m的US，和308 μ m和378 μ m的PA，分别。探头的能力，在离散和集成的照明/采集进行了测试，在明胶幻影与嵌入式光学吸收器的结果表明，能够获得体积双模态US和PA图像。
Visualization and detection of early-stage gynecological malignancies represents a challenge for imaging due to limiting factors including tissue accessibility, device ease of use, and accuracy of imaging modalities. In this work, we introduce a miniaturized phased-array ultrasound and photoacoustic endoscopic probe which is capable of providing structural, functional, and molecular data for the characterization of gynecologic disease. The proposed probe consists of a 64-element ultrasound phased-array transducer coupled to a fiber-optic light delivery system for co-registered ultrasound and photoacoustic imaging. The fabricated US and PA imaging endoscope's diameter is 7.5 mm, allowing for potential passage through the cervical canal and thus an intimate contact with gynecological tissues such as the cervical canal and uterus. The developed endoscopic probe was tested and characterized in a set of tissue-mimicking phantoms. US and PA resolutions were measured experimentally using 200 mu m diameter wires, resulting in apparent axial and lateral diameters of 289 mu m and 299 mu m for US, and 308 mu m and 378 mu m for PA, respectively. The probe's abilities to operate in both discrete and integrated illumination/acquisition were tested in gelatin phantoms with embedded optical absorbers with the results demonstrating the ability to acquire volumetric dual-modal US and PA images.