Role of Gut Microbiota in the Skeletal Response to PTH.
Role of Gut Microbiota in the Skeletal Response to PTH.
复制标题
肠道微生物区系在甲状旁腺素骨骼反应中的作用。
DOI：
10.1210/clinem/dgaa895
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发表时间：
2021-03-08
期刊：
影响因子：
--
通讯作者：
Pacifici R
中科院分区：
文献类型：
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作者：
Pacifici R
哺乳动物暴露的表面被100万亿种本土细菌、真菌和病毒定殖，创造了一个被称为人类微生物组的多样化生态系统。肠道微生物组是最丰富的微生物组，现在已知它调节出生后骨骼发育和骨骼主要内分泌调节因子的活性。甲状旁腺激素（PTH）是一种骨调节激素，需要肠道微生物组的元素来发挥其骨分解代谢和骨合成代谢作用。肠道微生物组如何调节骨骼对PTH的反应是深入研究的对象。涉及的机制包括细菌代谢物的吸收和扩散，如短链脂肪酸，以及免疫细胞从肠道到骨髓的运输。本文将重点介绍肠道微生物组如何沟通和调节骨髓细胞，以调节PTH的骨骼效应。
Exposed surfaces of mammals are colonized with 100 trillion indigenous bacteria, fungi, and viruses, creating a diverse ecosystem known as the human microbiome. The gut microbiome is the richest microbiome and is now known to regulate postnatal skeletal development and the activity of the major endocrine regulators of bone. Parathyroid hormone (PTH) is one of the bone-regulating hormone that requires elements of the gut microbiome to exert both its bone catabolic and its bone anabolic effects. How the gut microbiome regulates the skeletal response to PTH is object of intense research. Involved mechanisms include absorption and diffusion of bacterial metabolites, such as short-chain fatty acids, and trafficking of immune cells from the gut to the bone marrow. This review will focus on how the gut microbiome communicates and regulates bone marrow cells in order to modulate the skeletal effects of PTH.