Ecotoxicity test methods and environmental hazard assessment for engineered nanoparticles
Ecotoxicity test methods and environmental hazard assessment for engineered nanoparticles
复制标题
DOI：
10.1007/s10646-008-0215-z
复制
发表时间：
2008-07-01
期刊：
影响因子：
2.7
通讯作者：
Owen, Richard
中科院分区：
文献类型：
--
作者：
Crane, Mark;Handy, Richard D.;Owen, Richard
本文考虑了目前标准的生态毒性方法是否适合于评估工程纳米颗粒的危害。我们的结论是，在标准环境危害评估框架内使用的试验物种和生物终点的类型通常是适当的。然而，在适用于所有生态毒性测试指南的测试系统中，纳米颗粒暴露的特征存在相当大的不确定性，但口服纳米颗粒剂量的指南除外。这些问题包括在测试介质中加入和保持物质的方式；测试系统中纳米颗粒的测量和表征；更好地了解和报告影响测试介质中纳米颗粒行为的非生物因素；以及就如何报告剂量学数据达成一致。
This paper considers whether current standard ecotoxicity methods are fit for purpose for assessing the hazards of engineered nanoparticles. We conclude that the types of test species and biological endpoints used within standard environmental hazard assessment frameworks are generally appropriate. However, there are areas of considerable uncertainty associated with characterisation of nanoparticle exposure in test systems that apply to all ecotoxicity testing guidelines, except those in which dosing of nanoparticles is oral. These include the way in which the substance is dosed into, and maintained within, the test medium; measurement and characterisation of nanoparticles in the test system; better understanding and reporting of abiotic factors that influence behaviour of nanoparticles in the test medium; and agreement on how dosimetric data should be reported.