MICROINJECTION OF OXYTOCIN INTO LIMBIC-MESOLIMBIC BRAIN STRUCTURES DISRUPTS HEROIN SELF-ADMINISTRATION BEHAVIOR - A RECEPTOR-MEDIATED EVENT
MICROINJECTION OF OXYTOCIN INTO LIMBIC-MESOLIMBIC BRAIN STRUCTURES DISRUPTS HEROIN SELF-ADMINISTRATION BEHAVIOR - A RECEPTOR-MEDIATED EVENT
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DOI：
10.1016/0024-3205(87)90205-0
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发表时间：
1987-09-07
期刊：
影响因子：
6.1
通讯作者：
TELEGDY, G
中科院分区：
文献类型：
--
作者：
IBRAGIMOV, R;KOVACS, GL;TELEGDY, G
全身注射催产素（OXT）可减少海洛因耐受大鼠的自我给药。由于OXT能结合位点存在于边缘和中脑边缘脑区，因此研究了脑内微量注射OXT的影响。在海洛因耐受大鼠中，将OXT（2 ng）微量注射到延髓核的前背侧部分或腹侧海马中，破坏了海洛因的自我给药。海马内注射的效应持续时间比海马内注射的效应持续时间长。施用N α-乙酰-（2-0-甲基酪氨酸）-催产素（ACME-OXT），一种催产素受体的抑制剂，阻止海马内OXT注射对海洛因自我给药的破坏性作用。它的结论是边缘-中脑边缘系统的脑结构有一个重要的作用，在表达的破坏性行动的OXT海洛因自我管理。似乎OXT能结合位点介导OXT的作用。
The systemic injection of oxytocin (OXT) decreases the self-administration of heroin in heroin-tolerant rats. Since OXT-ergic binding sites are present in limbic and mesolimbic brain regions, the effects of intracerebral microinjections of OXT were investigated. In heroin-tolerant rats, the microinjection of OXT (2 ng) into the anterodorsal part of the nucleus accumbens or into the ventral hippocampus disrupted the self-administration of heroin. The effect of intrahippocampal microinjections lasted longer than that of intraacumbens injections. The administration of N.alpha.-acetyl-(2-0-methyltyrosine)-oxytocin (ACME-OXT), an inhibitor of oxytocin receptors, prevented the disruptive effect of intrahippocampal OXT injections on heroin self-administration. It is concluded that limbic-mesolimbic brain structures have an essential role in the expression of the disruptive action of OXT on heroin self-administration. It appears that OXT-ergic binding sites mediate the effects of OXT.