Enantio- and Regioselective Iridium-Catalyzed Allylic Hydroxylation
Enantio- and Regioselective Iridium-Catalyzed Allylic Hydroxylation
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DOI：
10.1021/ja109953v
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发表时间：
2011-02-23
影响因子：
15
通讯作者：
Helmchen, Guenter
中科院分区：
文献类型：
--
作者：
Gaertner, Martin;Mader, Steffen;Helmchen, Guenter
首次报道了不对称选择性烯丙基羟基化直接制备支链烯丙醇的方法。Biclidine被用作亲核试剂，与新的单组分Ir催化剂结合使用，该催化剂对空气和水稳定。优异的区域和对映体选择性已经实现了一组有代表性的基板。
The first enantioselective allylic hydroxylation to prepare branched allylic alcohols directly is described. Bicarbonate was used as nucleophile in conjunction with new single component Ir-catalysts, which are stable to air and water. Excellent regio- and enantioselectivities have been achieved with a representative set of substrates.