Magnetomotive contrast for in vivo optical coherence tomography
Magnetomotive contrast for in vivo optical coherence tomography
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DOI：
10.1364/opex.13.006597
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发表时间：
2005-08-22
期刊：
影响因子：
3.8
通讯作者：
Boppart, SA
中科院分区：
文献类型：
--
作者：
Oldenburg, AL;Toublan, FJJ;Boppart, SA
分子特异性对比可以极大地增强光学相干断层扫描（OCT）的生物医学用途。我们描述了一种对比机制，磁动势OCT (MMOCT)，其中调制的磁场诱导磁性纳米颗粒运动。纳米粒子的运动改变了OCT干涉图的振幅。通过减去样品的背景波动，实现了高特异性，并且对220 μ g/g磁铁矿纳米颗粒的灵敏度得到了证明。光学和机械校正组织幻影阐明了成像对比度与纳米颗粒浓度、成像深度、组织光学散射和磁场强度之间的关系。在非洲爪蟾蝌蚪活体中证实了MMOCT，其结果与相应的组织学一致。(c) 2005年美国光学学会。
Molecularly-specific contrast can greatly enhance the biomedical utility of optical coherence tomography (OCT). We describe a contrast mechanism, magnetomotive OCT (MMOCT), where a modulated magnetic field induces motion of magnetic nanoparticles. The motion of the nanoparticles modifies the amplitude of the OCT interferogram. High specificity is achieved by subtracting the background fluctuations of the specimen, and sensitivity to 220 mu g/g magnetite nanoparticles is demonstrated. Optically and mechanically correct tissue phantoms elucidate the relationships between imaging contrast and nanoparticle concentration, imaging depth, tissue optical scattering, and magnetic field strength. MMOCT is demonstrated in a living Xenopus laevis tadpole where the results were consistent with corresponding histology. (c) 2005 Optical Society of America.