Vertical interactions across ten parallel, stacked representations in the mammalian retina
Vertical interactions across ten parallel, stacked representations in the mammalian retina
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DOI：
10.1038/35069068
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发表时间：
2001-03-29
期刊：
影响因子：
64.8
通讯作者：
Werblin, F
中科院分区：
文献类型：
--
作者：
Roska, B;Werblin, F
哺乳动物的视觉系统通过一组独立的时空通道来分析世界（1，2）。这些通道的组织开始于视网膜（1，3），其中双极细胞的轴突终末和神经节细胞的树突状分支的精确分层表明在内丛状层（IPL）存在垂直堆叠的神经层（3-11）。相反，许多抑制性无长突细胞类别是多重或弥漫分层的（12），表明它们可能在层之间传递信息。基于神经节细胞的不同分层和生理特性，建议IPL包含视觉世界的平行表示集（3，7）体现在层中，并通过神经节细胞的类别传递到更高的中心，神经节细胞的树突在该层分叉。在这里，我们表明，每一层接收独特的和实质上不同的兴奋性和抑制性神经输入，整合形成至少十个不同的，平行的时空尖峰输出。这些地层的响应特性在时域中是有序的。通过GABA（C）受体的抑制提取神经表征中的空间边缘，并且似乎分离了各层的功能特性。我们描述了一种新形式的神经元相互作用，我们称之为“垂直抑制”，其作用不是横向的，而是在各层之间。
The mammalian visual system analyses the world through a set of separate spatio-temporal channels(1,2). The organization of these channels begins in the retina(1,3), where the precise laminations of both the axon terminals of bipolar cells and the dendritic arborizations of ganglion cells suggests the presence of a vertical stack of neural strata at the inner plexiform layer (IPL)(3-11), Conversely, many inhibitory amacrine cell classes are multiply or diffusely stratified(12), indicating that they might convey information between strata, On the basis of the diverse stratification and physiological properties of ganglion cells, it was suggested that the IPL contains a parallel set of representations of the visual world(3,7) embodied in the strata and conveyed to higher centres by the classes of ganglion cells whose dendrites ramify at that stratum. Here we show that each stratum receives unique and substantively different excitatory and inhibitory neural inputs that are integrated to form at least ten different, parallel spacetime spiking outputs. The response properties of these strata are ordered in the time domain. Inhibition through GABA(C) receptors extracts spatial edges in neural representations and seems to separate the functional properties of the strata, We describe a new form of neuronal interaction that we call 'vertical inhibition' that acts not laterally, but between strata.