Sleep homeostasis in infant rats
Sleep homeostasis in infant rats
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DOI：
10.1037/0735-7044.118.6.1253
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发表时间：
2004-12-01
影响因子：
1.9
通讯作者：
Johnson, ED
中科院分区：
文献类型：
--
作者：
Blumberg, MS;Middlemis-Brown, JE;Johnson, ED
体内平衡调节是睡眠的一个决定性特征，但很少在婴儿中进行研究。这项研究提出了一种自动剥夺睡眠的方法，当5天大的大鼠颈部肌肉变得无张力时，就对其进行电击。电击的强度总是设定在维持兴奋所需的最低水平。被剥夺的幼犬表现出睡眠压力的快速增加，这可以通过增加进入睡眠的尝试和随后的感觉阈值增加来证明；这种增加的感觉阈值不是由于外周受体的感觉适应。此外，肌阵挛性抽搐在剥夺30分钟期间受到抑制，导致恢复性睡眠期间出现反弹性抽搐。这些结果最早证明了哺乳动物睡眠的稳态调节。
Homeostatic regulation is a defining characteristic of sleep but has rarely been examined in infants. This study presents an automated method of sleep deprivation in which 5-day-old rats were shocked whenever the nuchal muscle became atonic. The intensity of shock was always set at the minimal level required to maintain arousal. Deprived pups exhibited rapid increases in sleep pressure, as evidenced by increased attempts to enter sleep and subsequent increases in sensory threshold; this increased sensory threshold was not due to sensory adaptation of peripheral receptors. In addition, myoclonic twitching was suppressed during the 30-min deprivation period, leading to rebound twitching during recovery sleep. These results provide the earliest demonstration of the homeostatic regulation of sleep in an altricial mammal.