Prognostic significance of L-type amino acid transporter 1 expression in resectable stage I-III nonsmall cell lung cancer.
Prognostic significance of L-type amino acid transporter 1 expression in resectable stage I-III nonsmall cell lung cancer.
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DOI：
10.1038/sj.bjc.6604235
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发表时间：
2008-02-26
影响因子：
8.8
通讯作者：
Mori, M.
中科院分区：
文献类型：
--
作者：
Kaira, K.;Oriuchi, N.;Imai, H.;Shimizu, K.;Yanagitani, N.;Sunaga, N.;Hisada, T.;Tanaka, S.;Ishizuka, T.;Kanai, Y.;Endou, H.;Nakajima, T.;Mori, M.
L氨基酸转运体1(LAT1)的临床意义尚不清楚，但许多实验研究表明LAT1与癌细胞的增殖有关。本研究的目的是评价LAT1在非小细胞肺癌(NSCLC)患者中的预后价值。我们回顾了连续321例病理完全切除的I-III期非小细胞肺癌患者。LAT1的表达和增殖活性(Ki-67标记指数)也被用免疫组织化学方法检测，并与肿瘤完全切除患者的预后相关。LAT1阳性表达163例(51%)，其中腺癌阳性率为29%(58/200)，鳞癌阳性率为91%(91/100)，大细胞癌阳性率为67%(14/21)。LAT1阳性患者的5年生存率(51.8%)明显低于LAT1阴性患者(87.8%；P<；0.001)。L型氨基酸转运体1的表达与淋巴结转移和疾病分期显著相关。多因素分析证实，LAT1阳性表达是预测预后不良的独立因素。LAT1表达与Ki-67标记指数呈正相关。LAT1表达是预测可切除I-III期NSCLC患者预后的一个有前景的病理指标。
The clinical significance of L-type amino acid transporter 1 (LAT1) expression remains unclear, whereas many experimental studies have demonstrated that LAT1 is associated with the proliferation of cancer cells. The purpose of this study was to evaluate the prognostic value of LAT1 in patients with nonsmall cell lung cancer (NSCLC). A total of 321 consecutive patients with completely resected pathologic stage I–III NSCLC were retrospectively reviewed. Expression of LAT1 and proliferative activity, as determined by the Ki-67 labelling index, was also evaluated immunohistochemically and correlated with the prognosis of patients who underwent complete resection of the tumour. Expression of LAT1 was positive in 163 patients (51%) (29% of adenocaricnoma (58 of 200 patients), 91% of squamous cell carcinoma (91 of 100 patients), and 67% of large cell carcinoma (14 of 21 patients)). The 5-year survival rate of LAT1-positive patients (51.8%) was significantly worse than that of LAT1-negative patients (87.8%; P<0.001). L-type amino acid transporter 1 expression was significantly associated with lymph node metastasis and disease stage. Multivariate analysis confirmed that positive expression of LAT1 was an independent factor for predicting a poor prognosis. There was a significant correlation between LAT1 expression and Ki-67 labelling index. LAT1 expression is a promising pathological factor to predict the prognosis in patients with resectable stage I–III NSCLC.
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影响因子：
9.6
作者：
Kaira, Kyoichi;Orinchi, Noboni;Mori, Masatomo
通讯作者：
Mori, Masatomo
影响因子：
6.4
作者：
Nawashiro, Hiroshi;Otani, Naoki;Endou, Hitoshi
通讯作者：
Endou, Hitoshi
影响因子：
4.8
作者：
Chairoungdua, A;Segawa, H;Kanai, Y
通讯作者：
Kanai, Y
影响因子：
3.5
作者：
Nakanishi, K;Matsuo, H;Kawai, T
通讯作者：
Kawai, T
影响因子：
64.8
作者：
OXENDER, DL;CHRISTENSEN, HN
通讯作者：
CHRISTENSEN, HN