Malignant spindle cell tumor arising in the mandible of a patient with florid osseous dysplasia
Malignant spindle cell tumor arising in the mandible of a patient with florid osseous dysplasia
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DOI：
10.1016/s1079-2104(99)70195-2
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发表时间：
1999-07-01
影响因子：
--
通讯作者：
Doyle, JL
中科院分区：
文献类型：
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作者：
Schneider, LC;Dolinsky, HB;Doyle, JL
华丽骨发育不良是颌骨牙槽突的非肿瘤性疾病，其特征在于多个骨病灶被纤维结缔组织替代，伴有牙骨质、骨或两者的逐渐沉积。病变与牙髓或牙周组织的炎性疾病无关。在发育完全的华丽骨发育不良中，在下颌骨两侧的牙槽骨中存在多个分叶状肿块，有时在上颌骨中。这是第一次报告的恶性肿瘤起源于颌骨的患者华丽的骨发育不良。一位54岁的黑人妇女的下颌骨被诊断为梭形细胞恶性肿瘤，尽管进行了广泛的手术和放疗，但患者在诊断恶性肿瘤后20个月死亡。
Florid osseous dysplasia is a non-neoplastic condition of the alveolar processes of the jaws characterized by the replacement of multiple foci of bone by fibrous connective tissue, accompanied by gradual deposition of cementum, bone, or both. The lesions are not associated with inflammatory diseases of the dental pulp or periodontal tissues. in fully developed florid osseous dysplasia, there are multiple lobulated masses in the alveolar bone bilaterally in the mandible and sometimes in the maxilla. This is the first report of a malignancy originating within the jaws of a patient with florid osseous dysplasia. A spindle cell malignancy was diagnosed in the mandible of a 54-year-old black woman whose jaw was affected by florid osseous dysplasia bilaterally Despite extensive surgery and radiotherapy, the patient died 20 months after diagnosis of the malignancy.