Risk of Leukemia and Multiple Myeloma Associated With Exposure to Benzene and Other Organic Solvents: Evidence From the Italian Multicenter Case-Control Study
Risk of Leukemia and Multiple Myeloma Associated With Exposure to Benzene and Other Organic Solvents: Evidence From the Italian Multicenter Case-Control Study
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DOI：
10.1002/ajim.20592
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发表时间：
2008-11-01
影响因子：
3.5
通讯作者：
Miligi, Lucia
中科院分区：
文献类型：
--
作者：
Costantini, Adele Seniori;Benvenuti, Alessandra;Miligi, Lucia
背景虽然苯诱导急性髓细胞白血病（AML）的能力已达成共识，但其对慢性淋巴细胞白血病和多发性骨髓瘤（MM）的影响仍存在争议。我们进行了一项基于人群的病例对照研究，以评估有机溶剂暴露与髓系和淋巴细胞白血病和MM风险之间的关系。方法收集了586例白血病（和1,278例人群对照），263例MM（和1,100例人群对照）。专家们评估了暴露在个人层面上的一系列chemicals.Results我们发现暴露于任何溶剂和AML之间没有关联。中/高苯暴露与慢性淋巴细胞白血病（OR= 1.8，95% CI = 0.9-3.9）和MM（OR=1.9，95% CI = 0.9-3.9）之间的相关性的点估计值升高。慢性淋巴细胞白血病的风险有所升高，虽然置信区间宽，从中/高暴露于二甲苯和甲苯，以及。结论我们没有证实苯和AML之间的已知关联，虽然这可能是解释了严格的监管苯在意大利近三十年前的研究开始。我们的研究结果支持苯、二甲苯和甲苯与慢性淋巴细胞白血病之间的相关性，以及苯与MM之间的相关性，与其他研究中观察到的AML相比，MM的潜伏期更长。美国工业医学杂志51：803-811，2008。(C)2008威利利斯公司
Background While there is a general consensus about the ability of benzene to induce acute myeloid leukemia (AML), its effects on chronic lymphoid leukemia and multiple myeloma (MM) are still under debate. We conducted a population-based case-control study to evaluate the association between exposure to organic solvents and risk of myeloid and lymphoid leukemia and MM.Methods Five hundred eighty-six cases of leukemia (and 1,278 population controls), 263 cases of MM (and 1,100 population controls) were, collected. Experts assessed exposure at individual level to a range of chemicals.Results We found no association between exposure to any solvent and AML. There were elevated point estimates for the associations between medium/high benzene exposure and chronic lymphatic leukemia (OR= 1.8, 95% CI = 0.9-3.9) and MM (OR=1.9, 95% CI = 0.9-3.9). Risks of chronic lymphatic leukemia were somewhat elevated, albeit with wide confidence intervals, from medium/high exposure to xylene and toluene as well.Conclusions We did not confirm the known association between benzene and AML, though this is likely explained by the strict regulation of benzene in Italy nearly three decades prior to study initiation. Our results support the association between benzene, xylene, and toluene and chronic lymphatic leukemia and between benzene and MM with longer latencies than have been observed for AML in other studies. Am.J.Ind.Med. 51:803-811, 2008. (C) 2008 Wiley-Liss, Inc.